Research Progress in Antineoplastic, Antibacterial, and Anti-inflammatory Activities of Seven-membered Heterocyclic Derivatives

Abstract

Seven-membered heterocyclic compounds are important drug scaffolds, because of their unique chemical structures. They widely exist in natural products and show a variety of biological activities. They have commonly been used in central nervous system drugs in the past 30 years. In the past decade, there are many studies on the activities of antitumor, antibacterial, etc. Herein, we summarize the research advances in different kinds of seven-membered heterocyclic compounds containing nitrogen, oxygen, and sulfur heteroatoms with antitumor, antisepsis, and anti-inflammation activities in the past ten years, which is expected to be beneficial to the development and design of novel drugs for the corresponding indications.

Skeletal Editing of Benzene Motif: Photopromoted Transannulation for Synthesis of DNA-Encoded Seven-Membered Rings

“…Seven-membered ring systems are prevalent in various natural products and bioactive pharmaceutical compounds, offering distinct advantages in terms of their affinity for biological receptors, oral bioavailability, and cell permeability (Scheme a) . These advantages stem from their relatively rigid and diverse three-dimensional spatial properties . Consequently, both academia and industry have shown significant interest in the synthesis and utilization of seven-membered ring compounds.…”