Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents

Wang, Lingyun; Xin, Shuqi; Tang, Hao; Cao, Derong

doi:10.6023/cjoc202005041

Cited by 3 publications

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“…Phototherapy is a potential therapeutic modality for cancer treatment because of its noninvasiveness, reduced damage to normal tissues, fewer side effects, and high selectivity compared with surgery, chemotherapy, and radiotherapy. Extensive research is being carried out to develop DPP-based photosensitizers for malignant tumor treatment [ 8 , 9 , 10 , 11 ]. As we know, the PDT effect is weakened due to hypoxia in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances of Diketopyrrolopyrrole Derivatives in Cancer Therapy and Imaging Applications

et al. 2023

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Cancer is threatening the survival of human beings all over the world. Phototherapy (including photothermal therapy (PTT) and photodynamic therapy (PDT)) and bioimaging are important tools for imaging–mediated cancer theranostics. Diketopyrrolopyrrole (DPP) dyes have received more attention due to their high thermal and photochemical stability, efficient reactive oxygen species (ROS) generation and thermal effects, easy functionalization, and tunable photophysical properties. In this review, we outline the latest achievements of DPP derivatives in cancer therapy and imaging over the past three years. DPP-based conjugated polymers and small molecules for detection, bioimaging, PTT, photoacoustic imaging (PAI)-guided PTT, and PDT/PTT combination therapy are summarized. Their design principles and chemical structures are highlighted. The outlook, challenges, and future opportunities for the development of DPP derivatives are also presented, which will give a future perspective for cancer treatment.

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