Research Progress in Relationship between Chronic Inflammation and Development of Esophageal Cancer

Abstract

As a common malignant tumor of the digestive tract, esophageal cancer has a high incidence in China, accounting for about half of the global incidence. The pathogenic factors are complicated, primarily related to eating diet, obesity, gastroesophageal reflux disease, and Barrett's esophagus. In this article, through the literature search of Web of Science, PubMed, and CNKI, we analyzed the transformation of inflammatory cells cytokines. We activated the inflammatory pathway in chronic inflammation of the esophagus. These form the tumor microenvironment suitable for tumorigenesis, proliferation, and metastasis, essential in transforming inflammation, metaplasia, and adenocarcinoma of the esophagus. Therefore, understanding the relationship between chronic inflammation and esophageal cancer development can provide new ideas for preventing and treating esophageal cancer.

Feasibility Study Utilizing NanoString’s Digital Spatial Profiling (DSP) Technology for Characterizing the Immune Microenvironment in Barrett’s Esophagus Formalin-Fixed Paraffin-Embedded Tissues

“…However, other extrinsic factors likely also play a role in the progression process. Together with genomic alterations, there is accumulating evidence that the inflammatory microenvironment (iME) plays a role in the progression process by contributing to inhibiting apoptosis, enabling immune evasion, and promoting proliferation, angiogenesis, invasion, and metastasis [13,14]. Studies in the microenvironment of BE have revealed the involvement of lymphoid cells (i.e., T cells, B cells, and NK cells) and myeloid-derived cells (i.e., macrophages, neutrophils, eosinophils), as well as their secreted cytokines and chemokines [15,16].…”