Research progress in the mechanism and treatment of osteosarcoma

Bian, Jichao; Liu, Yang; Zhao, Xiaowei; Meng, Chunyang; Zhang, Yuanmin; Duan, Yangmiao; Wang, Guodong

doi:10.1097/cm9.0000000000002800

Cited by 13 publications

(2 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given that the etiology of OS is complex, where multiple cell death mechanisms involved in OS's pathological process [49], it appears likely that the effective OS inhibitors should target multiple cell death processes simultaneously, which could also help address the problem of drug resistance [50]. The aberrant function of executioner and regulatory molecules involved in ferroptosis and apoptosis were extremely essential to the growth of different tumors [51], which also conferred resistance to anticancer drugs [52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cell

Zhang,

Hao,

Yang

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With no significant advances in the treatment of OS in recent ten years, discovering new and effective anti-OS drugs became our top priority. Oridonin has been proved to mediate anti-tumor impact on OS cells, although it’s mechanism of action has not been fully understood.Methods Here, we investigated the inhibitory effect of oridonin on OS cells and its underlying mechanisms. In 143B and U2OS cells, oridonin’s pro-apoptosis and pro-ferroptosis effects on cell death, cell proliferation, cell migration, iron accumulation, mitochondrial membrane potential and lipid peroxidation production were observed. Western blot (WB) and real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) were used to detect the expression levels of apoptosis and ferroptosis-relative proteins and genes. Iron assay Kit was used to evaluate the relative Fe2+ content. The mitochondrial membrane potential detection kit and ROS assay kit were used to evaluate the levels of mitochondrial membrane potential and lipid peroxidation production. The changes of oridonin’s inhibitory on malignant phenotype of OS cells were examined after treating OS cells with the ferroptosis inhibitor ferrostatin-1 (Fer-1).Results Oridonin potently inhibited OS cells viability and metastasis. Simultaneously, oridonin suppressed the expressions of BAX, cl-caspase3, SLC7A11, GPX4 and FTH1 proteins and mRNA, while promoting the expressions of Bcl-2 and ACSL4 in 143 and U2OS cells. Furthermore, we found that oridonin also boosted the accumulation of reactive oxygen species (ROS), encouraged the buildup of Fe2+, and decreased the mitochondrial membrane potential in OS cells, but this effect can be reversed by Fer-1.Conclusion Oridonin can trigger apoptosis and ferroptosis collaboratively in OS cells, making it a promising and effective agent for OS therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cell

Zhang,

Hao,

Yang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Osteosarcoma is a prevalent malignant tumor among children and adolescents [184,185]. ERK5 has been found to enhance the growth, proliferation, and migration of osteosarcoma cells, without diminishing cell viability.…”

Section: Erk5 and Bone Neoplasmsmentioning

confidence: 99%

Bone and Extracellular Signal-Related Kinase 5 (ERK5)

Wen,

Liu,

Zhou

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms. Recent studies have highlighted ERK5’s significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health. It also examines therapeutic strategies and future research avenues targeting ERK5.

show abstract

The role of disulfidptosis-associated LncRNA-LINC01137 in Osteosarcoma Biology and its regulatory effects on macrophage polarization

Tang,

Chen,

et al. 2024

Funct Integr Genomics

View full text Add to dashboard Cite

Research progress in the mechanism and treatment of osteosarcoma

Cited by 13 publications

References 84 publications

Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cell

Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cell

Bone and Extracellular Signal-Related Kinase 5 (ERK5)

The role of disulfidptosis-associated LncRNA-LINC01137 in Osteosarcoma Biology and its regulatory effects on macrophage polarization

Contact Info

Product

Resources

About