Research progress of biomimetic materials in oral medicine

Abstract

Biomimetic materials are able to mimic the structure and functional properties of native tissues especially natural oral tissues. They have attracted growing attention for their potential to achieve configurable and functional reconstruction in oral medicine. Though tremendous progress has been made regarding biomimetic materials, significant challenges still remain in terms of controversy on the mechanism of tooth tissue regeneration, lack of options for manufacturing such materials and insufficiency of in vivo experimental tests in related fields. In this review, the biomimetic materials used in oral medicine are summarized systematically, including tooth defect, tooth loss, periodontal diseases and maxillofacial bone defect. Various theoretical foundations of biomimetic materials research are reviewed, introducing the current and pertinent results. The benefits and limitations of these materials are summed up at the same time. Finally, challenges and potential of this field are discussed. This review provides the framework and support for further research in addition to giving a generally novel and fundamental basis for the utilization of biomimetic materials in the future.

Preliminary study on the preparation of antler powder/chitosan/β-glycerophosphate sodium/polyvinyl alcohol porous hydrogel scaffolds and their osteogenic effects

“…The amount of available alveolar bone within the mouth is key to the selection of treatment methods and treatment approaches in oral rehabilitation. Clinically, the loss of alveolar bone volume in patients can be caused by reasons such as tooth extraction, severe periodontitis, post-oral tumor surgery, cleft lip and palate, and congenital developmental abnormalities ( Bouziane et al, 2020 ; Luo et al, 2023 ; Zheng et al, 2023 ; Huang et al, 2024 ). The absence of adequate horizontal and vertical bone is a problem that can affect the survival rate of dental restoration ( Santos et al, 2023 ; Sun et al, 2023 ).…”