Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis

Abstract

Chronic kidney diseases usually cause renal interstitial fibrosis, the prevention, delay, and treatment of which is a global research hotspot. However, no definite treatment options are available in modern medicine. Chinese herbal medicine has a long history, rich varieties, and accurate treatment effects. Hitherto, many Chinese herbal medicine studies have emerged to improve renal interstitial fibrosis. This paper reviews the mechanisms of renal interstitial fibrosis and recent studies on the disease intervention with Chinese herbal medicine through literature search, intend to reveal the importance of Chinese herbal medicine in renal interstitial fibrosis. The results show that Chinese herbal medicine can improve renal interstitial fibrosis, and the effects of Chinese herbal medicine on specific pathological mechanisms underlying renal interstitial fibrosis have been explored. Additionally, the limitations and advantages of Chinese herbal medicine in the treatment of renal interstitial fibrosis, possible research directions, and new targets of Chinese herbal medicine are discussed to provide a basis for studies of renal interstitial fibrosis.

Protective effects and regulatory mechanisms of Shen-shuai-yi recipe on renal fibrosis in unilateral ureteral obstruction-induced mice

“…Although the etiology and pathological characteristics of renal fibrosis has been persistently investigated, there is no ideal drugs for preventing its progression and exhibiting no adverse side effects. TCM shows an extensive application potential in the prevention and treatment of renal fibrosis [ 12 ]. SSYR is prescribed base on traditional Chinese medicine theory and has been used in clinical practice for 30 years [ 13 ].…”

Significance of methylation-related genes in diagnosis and subtype classification of renal interstitial fibrosis

“…Low public awareness, high prevalence, high medical expenses, and a poor prognosis are all features of the significant public health threat known as chronic kidney disease (CKD), which affects people all over the world [ 1 ]. 697.5 million individuals worldwide, or 9.1% of the population, had CKD in 2017 [ 2 ]. Renal interstitial fibrosis (RIF) is a common pathological response to the widespread incidence of CKD.…”

Anti-Fibrotic Effect of Synthetic Noncoding Decoy ODNs for TFEB in an Animal Model of Chronic Kidney Disease

“…In addition, several inflammatory and metabolic molecular mechanisms, including TGF-β [ 10 ], WNT signaling [ 11 ], fibroblast growth factor receptor signaling [ 12 ], Notch signaling [ 13 ], Hedgehog signaling [ 14 ], endothelial [ 15 ] and podocyte glucocorticoid receptors [ 16 ], endothelial sirtuin 3 (SIRT3)-mediated mechanisms [ 17 ] and DPP-4 mediated mechanism [ 18 ], are known to be implicated in the pathogenesis of diabetic nephropathy. Factors that promote/inhibit fibrosis restrict each other, and the dynamic balance is lost, resulting in the formation of fibrosis [ 19 , 20 ]. The injured site of the renal interstitium can be rapidly infiltrated by a large number of inflammatory cells, aggravating fibrosis [ 19 ].…”

“…Factors that promote/inhibit fibrosis restrict each other, and the dynamic balance is lost, resulting in the formation of fibrosis [ 19 , 20 ]. The injured site of the renal interstitium can be rapidly infiltrated by a large number of inflammatory cells, aggravating fibrosis [ 19 ]. After prolonged renal injury, the infiltrated inflammatory cells release excessive pro-inflammatory cytokines, such as tumor necrosis factor (TNF) -α, interleukin (IL)-1β and IL-6, to clean up tissue debris, dead cells, and invading organisms from the injured site, as well as pro-fibrotic cytokines and growth factors [ 6 , 21 , 22 , 23 ].…”