Research progress of disinfection and disinfection by-products in China

Sun, Xuefeng; Chen, Miao; Wei, Dongbin; Du, Yuguo

doi:10.1016/j.jes.2019.02.003

Cited by 81 publications

(34 citation statements)

References 119 publications

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“…At the same time, the disinfection supply center should strictly control the standardization of the whole process of the use of sterile articles [ 9 , 10 ]. Studies have shown that the nonstandard management of sterile articles in clinical departments has reached 18.21%, mainly in the four links of receiving, distribution, storage, and use [ 11 , 12 ]. The management of sterile articles in clinical departments ensures patient safety.…”

Section: Discussionmentioning

confidence: 99%

The Supervision and Management Mode of Disinfection Supply Center Improves the Standardization of Sterile Goods Management in Clinical Departments

Jia

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. In daily inspection, the nonstandard management of sterile articles in clinical departments of hospitals often leads to the destruction of the sterilization effectiveness of sterile articles. Therefore, it is necessary to strengthen governance and improve this phenomenon. This study intends to investigate the mode in which the disinfection supply center participates in the supervision and management of the management of sterile items in clinical departments. It played a role in improving the standardization of the management of sterile articles in clinical departments and ensured the closed-loop management of the sterilization effectiveness of sterile articles. Methods. Every quarter, the disinfection supply center of our hospital will inspect the standardized management of sterile articles in all clinical departments of the hospital, mainly including the storage environment and facilities of sterile articles, the cleanliness of storage cabinets, placement principles, whether they are stored by category, and the quality and validity management of sterile articles. The quarterly inspection results were summarized and analyzed to find the existing problems and the causes. The disinfection supply center shall supervise the improvement. After the disinfection supply center inspected the standardized management of sterile articles in all clinical departments of the hospital for the first time according to the inspection contents, under the guidance and assistance of the nursing department and the hospital infection department, it improved the sterile article management system, conducted knowledge training for the whole hospital, and incorporated the standardized management of clinical sterile articles into the quality control inspection of the nursing department. In the later stage, the disinfection supply center is responsible for conducting routine inspection and supervision on the standardized management of sterile articles in all clinical departments of the hospital every quarter according to the inspection contents, including summarizing, analyzing, and urging the clinical departments to achieve the improvement of the management of sterile articles in clinical departments. Results. The standardization of aseptic articles after improvement was significantly higher than before and during improvement, and the qualified rate was significantly different (99.4% vs 97.9% vs 89.5%, P < 0.05 ). The average number of lost packages caused by nonstandard management in the department was significantly reduced. The average rate of lost sterile packages during and after the improvement was significantly lower than that before the improvement (10.5% vs 97.9% vs 89.5%, P < 0.05 ). It also effectively reduced the cost caused by the loss of sterile packages. Conclusion. The disinfection supply center participates in the quality control and management of sterile articles in the nursing department and regularly inspects and supervises the management of sterile articles in clinical departments. It can effectively improve the standardized management of sterile articles in clinical departments, ensure the safety of sterile articles, and form a closed loop of sterilization effectiveness.

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Section: Discussionmentioning

confidence: 99%

The Supervision and Management Mode of Disinfection Supply Center Improves the Standardization of Sterile Goods Management in Clinical Departments

Jia

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Xn-DBP compounds were newly formed by the chlorination treatment of DOM samples (e.g., new peaks clearly observed in Figures 3 and S9). Although precursor inspection is a useful filter rule for the accurate detection of Xn-DBPs in disinfected waters, it should be noted that precursors for "secondary Xn-DBPs" (formed by the decomposition of precursors via multiple degradation pathways) 28,29 were difficult to validate in the halogenated samples because of their multiple formation mechanisms. It has been reported that the major carbonyl Xn-DBPs contain a ketoacid structure, which is most likely generated from the phenyl ring cleavage of halogenated lignin-derived phenols in SRNOM.…”

Section: ■ Methods and Materialsmentioning

confidence: 99%

Development and Application of a High-Precision Algorithm for Nontarget Identification of Organohalogens Based on Ultrahigh-Resolution Mass Spectrometry

Fujii

Kwon

2020

Anal. Chem.

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The brominated and/or chlorinated organic compounds (referred to as organohalogens) are frequently detected in natural and engineered environments. However, the ultrahigh resolution mass spectrometry (UHR-MS)-based non-target identification of the organohalogens remains challenging due to the presence of vast number of halogenated and non-halogenated organic molecules in the same aqueous sample. In this study, a new algorithm, namely NOMDBP Code, was developed, based on natural organic matter (NOM) chemistry, to simultaneously identify organohalogens and non-organohalogens from the UHR-MS spectra of natural and engineered waters. In addition to isotopic pattern extraction, for the first time, three optional filter rules (namely selection of minimum non oxygen heteroatoms, inspection of newly formed halogenated disinfection byproducts [X23 DBPs] and precursors) were incorporated in our code, which can accurately identify DBPs associated peaks and further elucidate the X-DBPs generation and transformation mechanisms. The formulae assignment rate against previously reported 2,815 unique organohalogens and their 11,583 isotopologues was determined to be >97%. Application of our algorithm to disinfected NOM indicated that oxygen-containing X-DBPs species accounted for a majority of X-DBPs. Further, brominated X-DBPs (Br-DBPs) during disinfection process were characterized by higher degree of unsaturation compared to chlorinated X-DBPs (Cl-DBPs). Our algorithm also suggested that, in addition to electrophilic substitution and electrophilic addition reactions, the decomposition/transformation is another important mechanism in Br-DBPs formation. Results of this study highlight the superior potential of this code to efficiently detect yet-unknown organohalogens (including organohalogens with non-oxygen heteroatoms) in a non-target manner and identify their generation mechanism during the disinfection process File list (3) download file view on ChemRxiv DBP paper.pdf (1.10 MiB) download file view on ChemRxiv DBP paper_SI.pdf (2.69 MiB) download file view on ChemRxiv Supporting Information SI1 DBP list.xls (523.00 KiB)

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“…Applied current density is another important factor influencing CPBs formation because it can change the reaction rates and pathways on electrode surface [25,28]. Increasing attention has been paid to CBPs due to their potential human health risks, such as carcinogenicity or endocrine disruption, and the World Health Organization (WHO) and some countries have established stringent standards for the CBPs residues in drinking water [27,29]. These results demonstrated that CBPs residues were important indicators to evaluate the feasibility of urine treatment by electrolysis.…”

Section: Introductionmentioning

confidence: 99%

“…When BiO x /TiO 2 or IrO 2 electrodes were used to treat latrine wastewater, chlorinated organics and chlorate were the representative CBPs [25]. Based on the previous research, the influences of electrode material on CBPs formation were expected in connection with their chlorine evolution activity because the CBPs were the reaction by‐products of active chlorine and organic matters in urine [26, 27]. Applied current density is another important factor influencing CPBs formation because it can change the reaction rates and pathways on electrode surface [25, 28].…”

Section: Introductionmentioning

confidence: 99%

Revealing the mechanism of formation and transformation of chlorinated by‐products during electrolyzing synthetic urine using Ti/RuO_x‐IrO_x and BDD electrodes

Wang

Liu

et al. 2022

Fuel Cells

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In this study, the mechanism of chlorinated by‐products (CBPs) formation and transformation during urine electrolysis was comparatively investigated with active and nonactive electrodes. It was found that nutrients removal and CBPs formation was dominated by the chlorine evolution on the active Ti/RuOx‐IrOx electrodes. CBPs formation was inhibited by the ammonia and urea chlorination and kept at a relatively low level before chlorination breakpoint. After the concentration of organic CBPs (OCBPs) increasingly reaching the maximum as a result of the peak concentration of free chlorine, most free chlorine transformed into inorganic chlorination by‐products (ICBPs) with the chlorate as the main species. In contrast, the formation of CBPs on boron‐doped diamond (BDD) electrodes was jointly dominated by the direct oxidation and chlorine mediated oxidation, which resulted in the complete degradation of OCBPs and the accumulation of ICBPs throughout the electrolysis. The organics with high molecular weight readily formed CBPs. Moreover, higher current density would accelerate the production of ICBPs on both electrodes, although it could mitigate OCBPs production at chlorination breakpoint for Ti/RuOx‐IrOx anodes. Separation of chloride ions and organics with high molecular weight from urine using nanofiltration was proposed to mitigate the production of CBPs.

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Research progress of disinfection and disinfection by-products in China

Cited by 81 publications

References 119 publications

The Supervision and Management Mode of Disinfection Supply Center Improves the Standardization of Sterile Goods Management in Clinical Departments

The Supervision and Management Mode of Disinfection Supply Center Improves the Standardization of Sterile Goods Management in Clinical Departments

Development and Application of a High-Precision Algorithm for Nontarget Identification of Organohalogens Based on Ultrahigh-Resolution Mass Spectrometry

Revealing the mechanism of formation and transformation of chlorinated by‐products during electrolyzing synthetic urine using Ti/RuO_x‐IrO_x and BDD electrodes

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Research progress of disinfection and disinfection by-products in China

Cited by 81 publications

References 119 publications

The Supervision and Management Mode of Disinfection Supply Center Improves the Standardization of Sterile Goods Management in Clinical Departments

The Supervision and Management Mode of Disinfection Supply Center Improves the Standardization of Sterile Goods Management in Clinical Departments

Development and Application of a High-Precision Algorithm for Nontarget Identification of Organohalogens Based on Ultrahigh-Resolution Mass Spectrometry

Revealing the mechanism of formation and transformation of chlorinated by‐products during electrolyzing synthetic urine using Ti/RuOx‐IrOx and BDD electrodes

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Revealing the mechanism of formation and transformation of chlorinated by‐products during electrolyzing synthetic urine using Ti/RuO_x‐IrO_x and BDD electrodes