Research Progress ofα-Diazophosphonates

Enantioselective copper-catalyzed B–H bond insertion reaction of α-diazo phosphonates to access chiral α-boryl phosphonates

“…Implementing asymmetric carbene insertion into the B-H bond through transition metal catalysis emerges as a potent strategy for craing chiral boron-containing compounds. [19][20][21][22][23][24][25][26][27] Therefore, we hypothesized that a-diazo phosphonates might serve as suitable precursors for a-phosphoryl carbene, 28,29 which could undergo enantioselective B-H insertion to afford chiral aboryl phosphates.…”