Research Progress of Micro/Nanomotors for Cancer Treatment

Li, Ting; Wan, Mimi; Mao, Chun

doi:10.1002/cplu.202000532

Cited by 18 publications

(12 citation statements)

References 125 publications

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“…Nevertheless this work could also find applications in the micro and nano world. Actually, there is an increasing need to fully characterize the ACCEPTED MANUSCRIPT / CLEAN COPY dynamics of micro/nanomotors that are used as microrobotics in drug delivery for biomedical applications [32,33]. A MPLC coupled with a microscope could monitor and fully characterize the dynamics of such motors.…”

Section: Discussionmentioning

confidence: 99%

Rotational Doppler effect on reflection upon an ideal rotating propeller

Émile

Brousseau

et al. 2022

J. Opt. Soc. Am. B

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The rotational Doppler shift is the counterpart of the usual linear Doppler effect for rotating bodies. We study by an experimental approach coupled with theoretical considerations the rotational shift of a fundamental laser light reflected on an ideal rotating propeller. We decompose the reflected light on a Laguerre–Gaussian basis and show that only modes having the same rotational symmetry as the propeller are involved in the decomposition. The latter experience a frequency shift proportional to the rotation frequency of the propeller and the topological charge of the beam. Extensions of this work in the microwave domain are then considered.

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Section: Discussionmentioning

confidence: 99%

Rotational Doppler effect on reflection upon an ideal rotating propeller

Émile

Brousseau

et al. 2022

J. Opt. Soc. Am. B

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“…Many reviews regarding nanomotors have been published. [ 10,13–17 ] Of particular note, the article by Venugopalan et al. [ 17 ] ‘Fantastic Voyage of Nanomotors into the Cell’ provides an overview over the various architectures and motor types.…”

Section: Nanomotor State‐of‐artmentioning

confidence: 99%

A Biomolecular Toolbox for Precision Nanomotors

et al. 2023

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Figure 2. Chemically propelled nanomotors. a) Pt/Cr coated Janus nanomotors loaded with doxorubicin and functionalized with folic acid. Reproduced with permission. [54] Copyright 2014, John Wiley and Sons; b) pH-responsive ZIF-L nanomotors encapsulated with catalase and succinylated β-lactoglobulin, reproduced with permission. [55] Copyright 2019, John Wiley and Sons; c) vertically driven pH-responsive ZIF-L nanomotors encapsulating catalase and PDPA. Reproduced with permission. [34] Copyright 2019, Elsevier; d) Nanomotors constructed out of heparin, folic acid, and L-arginine were loaded with doxorubicin for the nitric oxide-mediated treatment of solid tumors. Reproduced under terms of the CC-BY license. [45] Copyright 2022, John Wiley and Sons; e) ZIF-8-coated up-conversion nanoparticles functionalised with glucose oxidase and catalase for photodynamic and oxygen starvation therapy of cancer cells. Reproduced with permission. [43] Copyright 2019, Elsevier; f) A jellyfish-shaped multi-metallic shell micromotor for DNA detection. Reproduced with permission. [57] Copyright 2014, John Wiley and Sons. g) Magnesium-based micromotor coated with titanium, PLGA embedded with clarithromycin and chitosan for the treatment of a stomach infection. Reproduced under terms of the CC-BY license. [59] Copyright 2017, Springer Nature; h) Mesoporous silica nanoparticles functionalized with urease and anti-FGFR3 for bladder treatment. Reproduced with permission. [60]

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“…Rapid blood flow, the mononuclear phagocyte system, and renal clearance are obstacles to tumor therapy. Moreover, the complex tumor environment hinders many targeted drug delivery systems, such as high interstitial fluid pressure that hampers tumor tissue penetration; hypoxia conditions that may limit some therapeutic agents; dense extracellular matrix; and abnormal tumor vasculature (Li et al, 2020). The challenges mentioned above make it very difficult to achieve effective treatment outcomes.…”

Section: Motile Drug Delivery By Micro/ Nanorobotsmentioning

confidence: 99%

“Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy

Zhang

Liu

Guan

et al. 2022

Front. Bioeng. Biotechnol.

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Traditional drug delivery systems opened the gate for tumor-targeted therapy, but they generally took advantage of enhanced permeability and retention or ligand-receptor mediated interaction, and thus suffered from limited recognition range (<0.5 nm) and low targeting efficiency (0.7%, median). Alternatively, micro/nanorobots (MNRs) may act as emerging “motile-targeting” drug delivery platforms to deliver therapeutic payloads, thereby making a giant step toward effective and safe cancer treatment due to their autonomous movement and navigation in biological media. This review focuses on the most recent developments of MNRs in “motile-targeting” drug delivery. After a brief introduction to traditional tumor-targeted drug delivery strategies and various MNRs, the representative applications of MNRs in “motile-targeting” drug delivery are systematically streamlined in terms of the propelling mechanisms. Following a discussion of the current challenges of each type of MNR in biomedical applications, as well as future prospects, several promising designs for MNRs that could benefit in “motile-targeting” drug delivery are proposed. This work is expected to attract and motivate researchers from different communities to advance the creation and practical application of the “motile-targeting” drug delivery platforms.

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Research Progress of Micro/Nanomotors for Cancer Treatment

Abstract: Biological micro/nanomotors refer to a kind of micro/nanomotors that rely on the motion capabilities of biologically active substances to propel the microdevices. Up to now, the correlational researches mainly focused on the use of those active [a

Cited by 18 publications

References 125 publications

Rotational Doppler effect on reflection upon an ideal rotating propeller

Rotational Doppler effect on reflection upon an ideal rotating propeller

A Biomolecular Toolbox for Precision Nanomotors

“Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy

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