Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma

Abstract

Osteosarcoma (OS) is a common malignant bone tumor that occurs mostly in children and adolescents. At present, surgery after chemotherapy or postoperative adjuvant chemotherapy is the main treatment plan. However, the efficacy of chemotherapeutic drugs is limited by the occurrence of chemotherapeutic resistance, toxicity to normal cells, poor pharmacokinetic performance, and drug delivery failure. The delivery of chemotherapy drugs to the bone to treat OS may fail for a variety of reasons, such as a lack of selectivity for OS cells, initial sudden release, short‐term release, and the presence of biological barriers (such as the blood‐bone marrow barrier). Nanomaterials are new materials with at least one dimension on the nanometer scale (1–100 nm) in three‐dimensional space. These materials have the ability to penetrate biological barriers and can accumulate preferentially in tumor cells. Studies have shown that the effective combination of nanomaterials and traditional chemotherapy can significantly improve the therapeutic effect. Therefore, this article reviews the latest research progress on the use of nanomaterials in OS chemotherapy.

Spatially Resolved Defect Characterization and Fidelity Assessment for Complex and Arbitrary Irregular 3D Printing Based on 3D P-OCT and GCode

“…In this study, three materials with wide applications and significant importance in the fields of bioengineering and medicine were selected, including hydroxyapatite (HAP), silicone and polycaprolactone (PCL). HAP stands out as the primary mineral building block of human bones and teeth and has immense utility, especially in bioprinting, bone repair and the production of biodegradable scaffolds [ 39 ]. Silicone is known for its outstanding physicochemical properties and robust environmental adaptability, enabling it to function effectively under complex conditions.…”