Research Progress of Nanomedicine-Based Mild Photothermal Therapy in Tumor

He, Xiang; Zhang, Shengtao; Tian, Yuhang; Cheng, Wen; Jing, Hui

doi:10.2147/ijn.s405020

Cited by 27 publications

(5 citation statements)

References 243 publications

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“…PPIX-PSilQ NPs induce cell death through the induction of ferroptosis, as evidenced by increased production of ROS and LPO ( Vadarevu et al, 2021 ). Mild photothermal therapy (mPTT, 42°C–45°C) has shown promising potential in tumor therapy with better biological effects and less side effects ( He et al, 2023 ). Fe@OVA-IR820 induces Fe 3+ -dependent ferroptosis-triggered ICD, which releases endogenous neoantigens and DAMPs that work synergistically with the exogenous antigen ovalbumin (OVA) to provoke an immune response.…”

Section: Induction Of Ferroptosis As a Novel Approach To Treat Melanomamentioning

confidence: 99%

Ferroptosis as a promising therapeutic strategy for melanoma

Ta,

Jiang,

Zhang

et al. 2023

Front. Pharmacol.

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Malignant melanoma (MM) is the most common and deadliest type of skin cancer and is associated with high mortality rates across all races and ethnicities. Although present treatment options combined with surgery provide short-term clinical benefit in patients and early diagnosis of non-metastatic MM significantly increases the probability of survival, no efficacious treatments are available for MM. The etiology and pathogenesis of MM are complex. Acquired drug resistance is associated with a pool prognosis in patients with advanced-stage MM. Thus, these patients require new therapeutic strategies to improve their treatment response and prognosis. Multiple studies have revealed that ferroptosis, a non-apoptotic form of regulated cell death (RCD) characterized by iron dependant lipid peroxidation, can prevent the development of MM. Recent studies have indicated that targeting ferroptosis is a promising treatment strategy for MM. This review article summarizes the core mechanisms underlying the development of ferroptosis in MM cells and its potential role as a therapeutic target in MM. We emphasize the emerging types of small molecules inducing ferroptosis pathways by boosting the antitumor activity of BRAFi and immunotherapy and uncover their beneficial effects to treat MM. We also summarize the application of nanosensitizer-mediated unique dynamic therapeutic strategies and ferroptosis-based nanodrug targeting strategies as therapeutic options for MM. This review suggests that pharmacological induction of ferroptosis may be a potential therapeutic target for MM.

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Section: Induction Of Ferroptosis As a Novel Approach To Treat Melanomamentioning

confidence: 99%

Ferroptosis as a promising therapeutic strategy for melanoma

Ta,

Jiang,

Zhang

et al. 2023

Front. Pharmacol.

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“…This approach minimizes hyperthermia‐related damage to non‐tumor cells while still effectively targeting tumor cells. [ 34,35 ]…”

Section: Introductionmentioning

confidence: 99%

Enhanced Renal Carcinoma Treatment via Synergistic Photothermal/Photodynamic Therapy Using Hittorf's Phosphorus‐Decorated Polymeric Carbon Nitride Heterostructure

Guan,

Li,

Yang

et al. 2024

Advanced Optical Materials

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Nanostructured heterojunctions offer a promising solution to overcome the limitations of narrow absorption spectra, limited penetration depths, and potential harm to healthy cells in phototherapy for clear cell renal cell carcinoma (ccRCC) treatment with nanomaterials. In this study, a heterostructure (PCN@HP) by decorating Hittorf's phosphorus nanorods onto biocompatible polymeric carbon nitride (PCN), enabling excitation by NIR light is designed. Compared with PCN and HP alone, the synthesized heterostructure generated localized heat upon broad absorption spectra of irradiation, boosting charge migration and separation, generating cytotoxic reactive oxygen species (ROS). Then, via in vitro and in vivo experiments, it is confirmed that the NIR‐mediated PCN@HP heterojunction is a safe and effective approach for synchronous photothermal and photodynamic therapy treatment of ccRCC. Collectively, the PCN@HP heterojunction holds great potential as a non‐invasive synergistic, dual‐mode therapeutic nanomedicine for efficient tumor nano‐therapy.

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“…Tumor mild-temperature photothermal therapy (PTT) has attracted considerable attention in recent years as it not only retains the advantages of PTT, such as excellent spatiotemporal selectivity, noninvasiveness, short treatment cycle, significant efficacy, and low risk of toxic side effects to humans, − but also avoids hyperthermia, which can cause inflammation, tumor metastasis, and intense pain. − Mild-temperature PTT relies on mild heat (42 to 45 °C) generated by a photothermal agent that affects enzymatic activity and lipid structure stability, causing cell death. However, the thermal defense mechanisms of tumor cells attenuate its therapeutic outcomes. − …”

Section: Introductionmentioning

confidence: 99%

Self-Delivery Nanomedicines Reverse Thermal Resistance to Enhance Tumor Mild-Temperature Photothermal Therapy

Lai,

Shi,

Xie

et al. 2024

Mol. Pharmaceutics

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Tumoral thermal defense mechanisms considerably attenuate the therapeutic outcomes of mild-temperature photothermal therapy (PTT). Thus, developing a simple, efficient, and universal therapeutic strategy to sensitize mild-temperature PTT is desirable. Herein, we report self-delivery nanomedicines ACy NPs comprising a near-infrared (NIR) photothermal agent (Cypate), mitochondrial oxidative phosphorylation inhibitor (ATO), and distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE−PEG 2000 ), which have a high drug-loading efficiency that can reverse tumoral thermal resistance, thereby increasing mildtemperature PTT efficacy. ACy NPs achieved targeted tumor accumulation and performed NIR fluorescence imaging capability in vivo to guide tumor PTT for optimized therapeutic outcomes. The released ATO reduced intracellular ATP levels to downregulate multiple heat shock proteins (including HSP70 and HSP90) before PTT, which reversed the thermal resistance of tumor cells, contributing to the excellent results of mild-temperature PTT in vitro and in vivo. Therefore, this study provides a simple, biosafe, advanced, and universal heat shock protein-blocking strategy for tumor PTT.

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Research Progress of Nanomedicine-Based Mild Photothermal Therapy in Tumor

Cited by 27 publications

References 243 publications

Ferroptosis as a promising therapeutic strategy for melanoma

Ferroptosis as a promising therapeutic strategy for melanoma

Enhanced Renal Carcinoma Treatment via Synergistic Photothermal/Photodynamic Therapy Using Hittorf's Phosphorus‐Decorated Polymeric Carbon Nitride Heterostructure

Self-Delivery Nanomedicines Reverse Thermal Resistance to Enhance Tumor Mild-Temperature Photothermal Therapy

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