Research progress of nanoparticle targeting delivery systems in bacterial infections

Jin, Ming Fang; He, Bin; Cai, Xiaoli; Lei, Zhixin; Sun, Taolei

doi:10.1016/j.colsurfb.2023.113444

Cited by 8 publications

(1 citation statement)

References 210 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 B and D) were also shown. Although the zeta-potential value of both Gram-positive and Gram-negative bacteria is negative, differences might be attributed to the structural disparity in cell wall composition between these kinds of bacteria [ [40] , [41] , [42] ]. Results were also in agreement with the higher ROS production obtained with the Gram-positive bacteria in comparison to the Gram-negative bacteria tested herein.…”

Section: Resultsmentioning

confidence: 99%

Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic

Scolari,

Páez,

Granero

2024

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic

Scolari,

Páez,

Granero

2024

Heliyon

View full text Add to dashboard Cite

Recent advances of aggregation‐induced emission in body surface organs

Li,

Zhang,

Liao

et al. 2023

Aggregate

View full text Add to dashboard Cite

The surface organs mainly comprise the superficial layers of various parts of the mammalian body, including the skin, eyes, and ears, which provide solid protection against various threats to the entire body. Damage to surface organs could lead to many serious diseases or even death. Currently, despite significant advancements in this field, there remain numerous enigmas that necessitate expeditious resolution, particularly pertaining to diagnostic and therapeutic objectives. The advancements in nanomedicine have provided a significant impetus for the development of novel approaches in the diagnosis, bioimaging, and therapy of superficial organs. The aggregation‐induced emission (AIE) phenomenon, initially observed by Prof. Ben Zhong Tang, stands out due to its contrasting behavior to the aggregation‐caused quenching effect. This discovery has significantly revolutionized the field of nanomedicine for surface organs owing to its remarkable advantages. In this review of literature, we aim to provide a comprehensive summary of recent advances of AIE lumenogen (AIEgen)‐based nanoplatforms in the fields of detection, diagnosis, imaging, and therapeutics of surface organ‐related diseases and discuss their prospects in the domain. It is hoped that this review will help attract researchers’ attention toward the utilization of this field for the exploration of a wider range of biomedical and clinical applications.

show abstract

Engineering Stimuli‐Responsive Materials for Precision Medicine

Zheng,

Yu,

Yao

et al. 2024

Small

View full text Add to dashboard Cite

Over the past decade, precision medicine has garnered increasing attention, making significant strides in discovering new therapeutic drugs and mechanisms, resulting in notable achievements in symptom alleviation, pain reduction, and extended survival rates. However, the limited target specificity of primary drugs and inter‐individual differences have often necessitated high‐dosage strategies, leading to challenges such as restricted deep tissue penetration rates and systemic side effects. Material science advancements present a promising avenue for these issues. By leveraging the distinct internal features of diseased regions and the application of specific external stimuli, responsive materials can be tailored to achieve targeted delivery, controllable release, and specific biochemical reactions. This review aims to highlight the latest advancements in stimuli‐responsive materials and their potential in precision medicine. Initially, we introduce disease‐related internal stimuli and capable external stimuli, elucidating the reaction principles of responsive functional groups. Subsequently, we provide a detailed analysis of representative pre‐clinical achievements of stimuli responsive materials across various clinical applications, including enhancements in the treatment of cancers, injury diseases, inflammatory diseases, infection diseases, and high‐throughput microfluidic biosensors. Finally, we discuss some clinical challenges, such as off‐target effects, long‐term impacts of nano‐materials, potential ethical concerns, and offer insights into future perspectives of stimuli‐responsive materials.

show abstract

Research progress of nanoparticle targeting delivery systems in bacterial infections

Cited by 8 publications

References 210 publications

Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic

Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic

Recent advances of aggregation‐induced emission in body surface organs

Engineering Stimuli‐Responsive Materials for Precision Medicine

Contact Info

Product

Resources

About