Research progress of natural products for the treatment of ischemic stroke

Abstract

Stroke is a leading cause of death and disability world-widely. The incidence rate of stroke has been increasing due to the aging population and lifestyle changes. At present, the only drug approved by the US Food and Drug Administration (FDA) for the treatment of ischemic stroke is tissue plasminogen activator (t-PA), but its clinical application is greatly limited because of its narrow time window and bleeding risk. Natural products have a long history of being used in traditional medicine with good safety, making them an important resource for the development of new drugs. Indeed, some natural products can target a variety of pathophysiological processes related to stroke, including oxidative stress, in lammation and neuronal apoptosis. Therefore, the development of high-e ficiency, lowtoxicity, safe and cheap active substances from natural products is of great significance for improving the treatment alternatives of patients with stroke. This article reviews the neuroprotective e fects of 33 natural compounds by searching recent related literature. Among them, puerarin, pinocembrin, quercetin, epigallocatechin-3-gallate (EGCG), and resveratrol have great potential in the clinical treatment of ischemic stroke. This review will provide a powerful reference for screening natural compounds with potential clinical application value in ischemic stroke or synthesizing new neuroprotective agents with natural compounds as lead compounds.

Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/Syk signaling pathway

“…In addition, the HE and Nissl staining also indicated the neuroprotection of IronQ-labeled MSCs is superior to MSCs and quercetin treatment, respectively. Preclinical studies have reported that quercetin improves behavioral recovery by ameliorating in ammatory response after stroke (24,44). It has been demonstrated that MSCs improve neurological outcomes and modulate the immune cells, including microglia, and neutrophils, to ameliorate in ammatory responses in rats after ICH (45,46).…”

Neuroprotective Effect of Polyphenol Extracts from Terminalia chebula Retz. against Cerebral Ischemia-Reperfusion Injury

“…Nrf2 pathway dysfunctions increase the brain infarct area and neuronal damage after ischemic stroke [ 36 ]. Furthermore, Nrf2 is a vital molecular target for the neuroprotective effects of numerous natural products by suppressing oxidative stress [ 37 ]. We provided evidence that Nrf2 protein expression was decreased after cerebral ischemia/reperfusion; however, TPE and TPB considerably increased Nrf2 protein expression.…”

Verbena officinalis (Verbenaceae): Pharmacology, Toxicology and role in female health

“…Moreover, Cornin, an iridoid glycoside derived from the fruits can increase proliferation, invasion, and lumen formation in vitro, resulting in angiogenesis. Cornin increased the proliferation of rat arterial smooth muscle cells (RASMC) and the expression of tissue homeostasis regulators like Wnt5a, β-catenin, cyclin D1 and angiopoietin-1, confirming that it can reduce BBB leakage, promote angiogenesis and functional recovery after stroke (50).…”