Research Progress of Oxidative Stress and MicroRNAs in the Prevention of Catheter-Related Thrombus Under Resistance Exercise

Cui, Wen; Ying, Yanping; Yu, Fan; Zhou, Jilin

doi:10.1177/1076029620931931

Cited by 4 publications

(3 citation statements)

References 80 publications

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“…However, it has been shown that increased levels of oxidative stress can be an important mechanism in the pathophysiology of these risk factors, leading to increased levels of oxidized LDL (ox-LDL), increased thrombus formation, endothelial dysfunction, and the development of atherosclerotic plaques [ 7 , 8 ]. Therefore, it can be deduced that antioxidants may be effective in PAD treatment [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Antioxidants in the Treatment of Peripheral Arterial Disease: A Systematic Review

Keramat¹,

Sharebiani²,

Patel

et al. 2022

Antioxidants

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Peripheral arterial disease (PAD) has a worldwide prevalence and is a significant cause of cardiovascular morbidity and mortality. Due to its high prevalence and higher rates of ischemic cardiovascular and lower-extremity events, its treatment is essential. Increased levels of oxidative stress cause disease. This review aimed to evaluate different studies of antioxidant treatments for PAD patients. A systematic search for relevant studies was performed on the PubMed, SCOPUS, and ScienceDirect databases, and 18 studies fulfilled the inclusion criteria. In total, 16.6% of the studies used natural antioxidants, and 83.3% used synthetic antioxidants. The reviewed studies show that natural antioxidants were completely effective in treating PAD, and synthetic antioxidants showed effective results in only 53% of the studies. A less-than-optimal pro-oxidant–antioxidant balance does not improve the symptoms of PAD. In conclusion, antioxidants in their natural forms are more effective for PAD patients, and ensuring the optimal pro-oxidant–antioxidant balance is an effective method for managing treatment with antioxidants.

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Section: Discussionmentioning

confidence: 99%

The Potential Role of Antioxidants in the Treatment of Peripheral Arterial Disease: A Systematic Review

Keramat¹,

Sharebiani²,

Patel

et al. 2022

Antioxidants

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“…Therefore, antioxidant effects can be used to prevent endothelial damage and ultimately improve thrombus formation. MDA is produced by the peroxidation of polyunsaturated fatty acids on the cell membrane, which can further cause the tissue oxidative damage and is usually used as an indicator of oxidative stress in cell membranes [ 23 ]. Studies have shown that compared with healthy controls, patients with venous thrombosis have higher levels of MDA in the body [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Chuanxiong Rhizoma, the dried rhizome of Ligusticum chuanxiong Hort., is a commonly used drug for promoting blood circulation and dissipating congestion. Tetramethylpyrazine (TMP), the main active ingredient of Ligusticum chuanxiong, has significant antioxidant, anti-inflammatory, and vascular protective effects. However, the protective properties and underlying mechanisms of TMP against endothelial injury-induced insufficient angiogenesis and thrombosis have not been elucidated. Therefore, we aimed to explore the protective effects of TMP on endothelial injury and its antithrombotic effects and study the mechanism. In vitro experiments showed that TMP could alleviate hydrogen peroxide– (H2O2–) induced endothelial injury of human umbilical vein endothelial cells (HUVECs) and the protective mechanism might be related to the regulation of MAPK signaling pathway, and its antioxidative and antiapoptotic effects. In vivo experiments showed that TMP restored PTK787-induced damage to intersegmental vessels (ISVs) in Tg(fli-1: EGFP)y1 transgenic (Flik) zebrafish larvae. Similarly, adrenalin hydrochloride– (AH–) induced reactive oxygen species (ROS) production and thrombosis in AB strain zebrafish were inhibited by TMP. RT-qPCR assay proved that TMP could inhibit the expression of fga, fgb, fgg, f7, and von Willebrand factor (vWF) mRNA to exert an antithrombotic effect. Our findings suggest that TMP can contribute to endothelial injury protection and antithrombosis by modulating MAPK signaling and attenuating oxidative stress and antiapoptosis.

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“…Resistance exercise not only improves vascular endothelial function and blood ow velocity, but also inhibits the adverse effects of anticoagulants such as warfarin and heparin and prevents the formation of CRT [7]. As a primary form of prevention,resistance exercise is safe, noninvasive, straightforward to learn, economical for patients, and easy to popularize;it has been recommended by clinical guidelines for daily prevention and rehabilitation training of cardiovascular diseases [8] .…”

Section: Introductionmentioning

confidence: 99%

Resistance Exercise Induces Heme Oxygenase-1 Expression to Promote Macrophage Polarization and Accelerate Catheter-related Thrombolysis and Recanalization in Rats

Wei¹,

Zhao²,

Jiang³

et al. 2021

Preprint

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IntroductionCatheter-related thrombosis (CRT) is a major complication of central venous catheters. Resistance exercise to prevent CRT formation has been demonstrated, but there are few studies of CRT dissolution and recanalization. In this study, we focused on resistance exercise, heme oxygenase-1 (HO-1), and macrophage polarization to investigate the mechanism of resistance exercise accelerating thrombolysis and recanalization, providing a theoretical basis for resistance exercise adjuvant therapy of CRT.MethodsA rat CRT model was established and Intervened with resistance exercise and injection of HO-1 agonist cobalt protoporphyrin (COPP) and the inhibitor tin protoporphyrin IX(SnPP).Thrombolysis and recanalization were observed by hematoxylin and eosin(H&E). Neovascularization was detected by immunohistochemical CD31 staining. The levels of HO-1, IL-6, and IL-10 in the rat sera were determined by enzyme-linked immunosorbent assay (ELISA). The relative expression levels of HO-1, Arg-1, HO-1, CD206, and CD80 mRNA were detected by quantitative polymerase chain reaction (qPCR). The colocalization expression of HO-1 with CD206 and CD86 were detected by immunofluorescence.ResultsResistance exercise for 28 days could induce HO-1 expression, decrease IL-6 level, increase IL-10 level, increase Arg-1 and CD206 expression, decrease INOS and CD80 expression, and increase CD31 expression, and the co-localization expression of HO-1 and CD206 was significantly higher than that of HO-1 and CD86.ConclusionAfter 28 days of resistance exercise, mechanical stimulation can mediate the expression of HO-1 in macrophages, promote the polarization of M2 macrophages, exert the effects of anti-inflammation and promoting angiogenesis, and accelerate the dissolution and recanalization of CRT.

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Research Progress of Oxidative Stress and MicroRNAs in the Prevention of Catheter-Related Thrombus Under Resistance Exercise

Cited by 4 publications

References 80 publications

The Potential Role of Antioxidants in the Treatment of Peripheral Arterial Disease: A Systematic Review

The Potential Role of Antioxidants in the Treatment of Peripheral Arterial Disease: A Systematic Review

Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish

Resistance Exercise Induces Heme Oxygenase-1 Expression to Promote Macrophage Polarization and Accelerate Catheter-related Thrombolysis and Recanalization in Rats

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