Research Progress of Preparation Technology of Ion-Exchange Resin Complexes

Zhang, Tianyi; Du, Ruofei; Wang, Youjie; Hu, Jisheng; Wu, Fei; Feng, Yi

doi:10.1208/s12249-022-02260-6

Cited by 18 publications

(5 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in PCC, these two peaks were not present, as indicated by the red-dotted square in Figure 3 [ 37 ]. Similar to previous studies, the peak band at 2200~2400 cm −1 was weakened in PCC compared to the higher intensity peak band in the physical mixture [ 22 , 38 ]. This result means the existence of structural interaction between PPD and CER, which is expected due to the electrostatic coupling of piperadine from PPD and sulfonate from CER [ 39 ].…”

Section: Resultssupporting

confidence: 89%

“…Ion-exchange resins can be divided into two classes: cation- and anion-exchange resins. Cation-exchange resins (CERs; Figure 1 B) are suitable as carriers for cationic drugs, and the functional group of CERs used in pharmaceuticals is mainly carboxylic acid (-COOH) or sulfonic acid (-SO 3 H) [ 22 ]. The degree of their dissociation is strongly influenced by the solution pH.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Paliperidone–Cation Exchange Resin Complexes of Different Particle Sizes for Controlled Release

et al. 2023

View full text Add to dashboard Cite

This study aimed to develop electrolyte complexes of paliperidone (PPD) with various particle sizes using cation-exchange resins (CERs) to enable controlled release (both immediate and sustained release). CERs of specific particle size ranges were obtained by sieving commercial products. PPD–CER complexes (PCCs) were prepared in an acidic solution of pH 1.2 and demonstrated a high binding efficiency (>99.0%). PCCs were prepared with CERs of various particle sizes (on average, 100, 150, and 400 μm) at the weight ratio of PPD to CER (1:2 and 1:4). Physicochemical characterization studies such as Fourier-transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction, and scanning electron microscopy between PCCs (1:4) and physical mixtures confirmed PCC formation. In the drug release test, PPD alone experienced a complete drug release from PCC of >85% within 60 min and 120 min in pH 1.2 and pH 6.8 buffer solutions, respectively. Alternatively, PCC (1:4) prepared with CER (150 μm) formed spherical particles and showed an almost negligible release of PPD in pH 1.2 buffer (<10%, 2 h) while controlling the release in pH 6.8 buffer (>75%, 24 h). The release rate of PPD from PCCs was reduced with the increase in CER particle size and CER ratio. The PCCs explored in this study could be a promising technology for controlling the release of PPD in a variety of methods.

show abstract

Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Paliperidone–Cation Exchange Resin Complexes of Different Particle Sizes for Controlled Release

et al. 2023

View full text Add to dashboard Cite

show abstract

“…During the formation of DRCs, IERs can exchange ions with high-affinity ions, which, in this case, are drugs. These IERs can possess either cationic or anionic properties, and the strength of ion exchange relies on the affinity of their functional groups [52]. However, for the ion exchange process to occur between the IER and the drug, the drug needs to be in its salt form, preferably as hydrochloride or hydrobromide.…”

Section: Drug-resin Complexesmentioning

confidence: 99%

Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation—Where Are We Now?

Patil,

Vemula,

Narala

et al. 2024

AAPS PharmSciTech

View full text Add to dashboard Cite

Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) offers an extremely resourceful customizable mixer that is used for continuous compounding and granulation by using different combinations of conveying elements, kneading elements (forward and reverse configuration), and distributive mixing elements. TSE is thus efficiently utilized for dry, wet, or melt granulation not only to manufacture dosage forms such as tablets, capsules, or granule-filled sachets, but also for designing novel formulations such as dry powder inhalers, drying units for granules, nanoextrusion, 3D printing, complexation, and amorphous solid dispersions. Over the past decades, combined academic and pharmaceutical industry collaborations have driven novel innovations for HME technology, which has resulted in a substantial increase in published articles and patents. This article summarizes the challenges and models for executing HME scale-up. Additionally, it covers the benefits of continuous manufacturing, process analytical technology (PAT) considerations, and regulatory requirements. In summary, this well-designed review builds upon our earlier publication, probing deeper into the potential of twin-screw extruders (TSE) for various new applications. Graphical Abstract

show abstract

“…Ion-Exchange Resins (IER) are high molecular weight, water-insoluble, highly cross-linked polymeric structures with ionizable cationic or anionic functional groups. During the DRC formation, the ionizable functional groups on IER can exchange their ions with similarly charged strong affinitive drug ions in a solution [110]. The interaction between the drug and IER in a suitable solution can be described in the following equation-2.…”

Section: Drug-resin Complexes (Drc)mentioning

confidence: 99%

Drug complexes: Perspective from Academic Research and Pharmaceutical Market

et al. 2023

View full text Add to dashboard Cite

Despite numerous research efforts, drug delivery through the oral route remains a major challenge to formulation scientists. The oral delivery of drugs poses a significant challenge because more than 40% of new chemical entities are practically insoluble in water. Low aqueous solubility is the main problem encountered during the formulation development of new actives and for generic development. A complexation approach has been widely investigated to address this issue, which subsequently improves the bioavailability of these drugs. This review discusses the various types of complexes such as metal complex (drug-metal ion), organic molecules (drug-caffeine or drug-hydrophilic polymer), inclusion complex (drug-cyclodextrin), and pharmacosomes (drug-phospholipids) that improves the aqueous solubility, dissolution, and permeability of the drug along with the numerous case studies reported in the literature. Besides improving solubility, drug-complexation provides versatile functions like improving stability, reducing the toxicity of drugs, increasing or decreasing the dissolution rate, and enhancing bioavailability and biodistribution. Apart, various methods to predict the stoichiometric ratio of reactants and the stability of the developed complex are discussed. Graphical Abstract

show abstract

Research Progress of Preparation Technology of Ion-Exchange Resin Complexes

Cited by 18 publications

References 77 publications

Paliperidone–Cation Exchange Resin Complexes of Different Particle Sizes for Controlled Release

Paliperidone–Cation Exchange Resin Complexes of Different Particle Sizes for Controlled Release

Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation—Where Are We Now?

Drug complexes: Perspective from Academic Research and Pharmaceutical Market

Contact Info

Product

Resources

About