Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review)

Abstract

Dyslipidemia is an umbrella term for a range of lipid metabolic disorders in the body. This condition has been widely reported to greatly increase the risk of cardiovascular diseases, threatening human health. In recent years, advances in molecular biology have deepened understanding of the dyslipidemia-related signaling pathways and specific mechanisms underlying dyslipidemia. Signaling pathways possess the ability to transmit an extracellular signal to the inside of the cell, leading to specific biological effects. Lipid metabolism disorders and lipid levels in the blood are frequently affected by aberrant alterations in the dyslipidemia-related signaling pathways. Therefore, further investigations into these pathways are required for the prevention and treatment of dyslipidemia. The present review summarizes the characteristics of six dyslipidemia-associated signaling pathways: Peroxisome proliferator-activated receptor, adenosine monophosphate-activated protein kinase, farnesoid X receptor, forkhead box O, adipocytokine and cyclic adenosine monophosphate signaling pathways. In particular, specific focus was placed on previous experimental studies and reports on the intervention effects of natural substances (compounds from animals, plants, marine organisms and microorganisms) on dyslipidemia.

Analysis of the Mechanism of Intervention of Fangxiangxiaozhi Prescription on Dyslipidemia Based on Network Pharmacology and Molecular Docking

“…Adipose tissue, an important endocrine organ in the human body, has various signal pathway networks, whose function depends on the synthesis and release of cytokines [16] . The adipocytokine signaling pathway belongs to the signaling pathways related to dyslipidemia [17] . A study has shown that the fluid shear stress of arteries directly regulated the expression of interferon regulatory factors in arterial endothelial cells and downstream inflammatory response, which is an important mediator of dyslipidemia and atherosclerosis [18] .…”