Research progress of the effects of bisphenol analogues on the intestine and its underlying mechanisms: A review

Zhu, Min; Zeng, Ran; Wu, Dan; Li, Yuanyuan; Chen, Ting; Wang, Aijie

doi:10.1016/j.envres.2023.117891

Cited by 7 publications

(1 citation statement)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, commercial MNPLs are devoid of additives and contaminants unlike MNPLs resulting from the degradation of industrial plastics. It is known that some plastic additives and contaminants have their own intestinal toxicity, such as bisphenols and phthalates [75,76]. Some plastic contaminants such as heavy metals and persistent organic pollutants could also present combined intestinal toxicity with MNPLs [77].…”

Section: Resultsmentioning

confidence: 99%

Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence

Djouina,

Loison,

Body-Malapel

2024

Microplastics

View full text Add to dashboard Cite

The tremendous plastic production and poor post-use management are current and future sources of environmental and human contamination due to their degradation products: microplastics and nanoplastics (MNPLs). Methodological developments have allowed MNPLs to be detected in an increasing variety of human foods, as well as in stool and colonic mucosa. It was suggested early that the direct contact between MNPLs and intestinal tissues could represent a potential risk for human health. In order to assess this, over the last 3 years, numerous studies have evaluated the impact of MNPL ingestion on intestinal homeostasis in rodents. This comprehensive review reports the preclinical studies published between January 2021 and January 2024, and analyzes their contributions as well as their shortcomings. It shows that evidence is accumulating of the intestinal toxicity of spherical MNPLs, which lead to pro-inflammatory, pro-oxidative, barrier-disruptive and dysbiotic effects. However, the available literature has addressed only a minor part of the potential health issues of MNPLs. Many parameters contributing to MNPL toxicity need to be better taken into account in future studies. Particular attention should be paid to improve the representativeness of MNPLs, as well as to better consider the susceptibility factors of MNPL toxicity, generated especially by an underlying pathology or pathological imprinting.

show abstract

Section: Resultsmentioning

confidence: 99%