Research Progress of Titanium-Based Alloys for Medical Devices

Baltatu, Madalina Simona; Vizureanu, Petrica; Sandu, Andrei Victor; Solcan, Carmen; Hritcu, Luminița Diana; Spataru, Mihaela Claudia

doi:10.3390/biomedicines11112997

Cited by 4 publications

(1 citation statement)

References 67 publications

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“…Typically, metals such as platinum (Pt), titanium alloys, and stainless steels, which are also compatible with the body, are used as implants in orthopedic surgery [2][3][4][5][6][7][8]. Secondary surgery to remove the implant, which causes physical and mental pain for the patient, as well as the phenomenon of stress shielding on the tissue surrounding the implant, was always a challenge for researchers [9,10].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Magnesium–Magnesium Oxide Nanoparticle Composites for Biomedical Applications

Saberi,

Baltatu,

Vizureanu

2024

Bioengineering

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Magnesium (Mg) is considered an attractive option for orthopedic applications due to its density and elastic modulus close to the natural bone of the body, as well as biodegradability and good tensile strength. However, it faces serious challenges, including a high degradation rate and, as a result, a loss of mechanical properties during long periods of exposure to the biological environment. Also, among its other weaknesses, it can be mentioned that it does not deal with bacterial biofilms. It has been found that making composites by synergizing its various components can be an efficient way to improve its properties. Among metal oxide nanoparticles, magnesium oxide nanoparticles (MgO NPs) have distinct physicochemical and biological properties, including biocompatibility, biodegradability, high bioactivity, significant antibacterial properties, and good mechanical properties, which make it a good choice as a reinforcement in composites. However, the lack of comprehensive understanding of the effectiveness of Mg NPs as Mg matrix reinforcements in mechanical, corrosion, and biological fields is considered a challenge in their application. While introducing the role of MgO NPs in medical fields, this article summarizes the most important results of recent research on the mechanical, corrosion, and biological performance of Mg/MgO composites.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Magnesium–Magnesium Oxide Nanoparticle Composites for Biomedical Applications

Saberi,

Baltatu,

Vizureanu

2024

Bioengineering

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Development of Biocompatible Coatings with PVA/Gelatin Hydrogel Films on Vancomycin-Loaded Titania Nanotubes for Controllable Drug Release

Wattanavijitkul,

Khamwannah,

Lohwongwatana

et al. 2024

ACS Omega

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This study investigates the utilization of poly(vinyl alcohol) (PVA)/gelatin hydrogel films cross-linked with glutaraldehyde as a novel material to coat the surface of vancomycin-loaded titania nanotubes (TNTs), with a focus on enhancing biocompatibility and achieving controlled vancomycin release. Hydrogel films have emerged as promising candidates in tissue engineering and drugdelivery systems due to their versatile properties. The development of these hydrogel films involved varying the proportions of PVA, gelatin, and glutaraldehyde to achieve the desired properties, including the gel fraction, swelling behavior, biocompatibility, and biodegradation. Among the formulations tested, the hydrogel with a PVA-to-gelatin ratio of 25:75 and 0.2% glutaraldehyde was selected to coat vancomycin-loaded TNTs. The coated TNTs demonstrated slower release of vancomycin compared with the uncoated TNTs. In addition, the coated TNTs demonstrated the ability to promote osteogenesis, as evidenced by increased alkaline phosphatase activity and calcium accumulation. The vancomycin-loaded TNTs coated with hydrogel film demonstrated effectiveness against both E. coli and S. aureus. These findings highlight the potential benefits and therapeutic applications of using hydrogel films to coat implant materials, offering efficient drug delivery and controlled release. This study contributes valuable insights into the development of alternative materials for medical applications, thereby advancing the field of biomaterials and drug delivery systems.

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On β-titanium alloys: tailoring gamma-ray, and neutron transmission properties for nuclear and biomedical applications

AlMisned,

Baykal,

Alkarrani

et al. 2024

Metall. Res. Technol.

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This study explores the gamma-ray and neutron transmission properties of β-Titanium alloys pivotal for their performance in nuclear and biomedical applications. Utilizing the Monte Carlo N-Particle (MCNP 6.3) simulations, we analyzed a spectrum of Ti-based alloys modified with elements like molybdenum (Mo), zirconium (Zr), niobium (Nb), and hafnium (Hf) to determine their radiation attenuation properties. Key parameters such as mass and linear attenuation coefficients, half-value layers, exposure buildup factors, and fast neutron effective removal cross-section values were computed, revealing significant enhancements in attenuation with the addition of high-Z elements. Specifically, alloys like Ti50Hf50 and (TiZr)40Cu60 exhibited superior photon and fast neutron attenuation due to their high-Z constituents. For instance, Ti50Hf50 showed a mass attenuation coefficient of 0.217 cm2/g and a half-value layer of 2.97 cm at 0.1 MeV photon energy, while (TiZr)40Cu60 demonstrated similar performance with a mass attenuation coefficient of 0.198 cm2/g and a half-value layer of 3.26 cm. These alloys also exhibited effective neutron removal cross-section values of 0.115 cm−1 and 0.130 cm−1, respectively. Alloys with lower-Z elements showed less attenuation, which may be beneficial in scenarios requiring reduced radiographic contrast in biomedical applications. The MCNP outcomes were in strong agreement with standard data, affirming the accuracy of computational methods in predicting material behavior. In conclusion, tailored alloy development is crucial for improving radiation shielding and diagnostic visualization, with broader implications for patient safety and treatment efficacy.

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Research Progress of Titanium-Based Alloys for Medical Devices

Cited by 4 publications

References 67 publications

Recent Advances in Magnesium–Magnesium Oxide Nanoparticle Composites for Biomedical Applications

Recent Advances in Magnesium–Magnesium Oxide Nanoparticle Composites for Biomedical Applications

Development of Biocompatible Coatings with PVA/Gelatin Hydrogel Films on Vancomycin-Loaded Titania Nanotubes for Controllable Drug Release

On β-titanium alloys: tailoring gamma-ray, and neutron transmission properties for nuclear and biomedical applications

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