Research Progress of UiO-66-Based Electrochemical Biosensors

Abstract

UiO-66, as a member of the MOFs families, is widely employed in sensing, drug release, separation, and adsorption due to its large specific surface area, uniform pore size, easy functionalization, and excellent stability. Especially in electrochemical biosensors, UiO-66 has demonstrated excellent adsorption capacity and response signal, which significantly improves the sensitivity and specificity of detection. However, the existing application research remains in its infancy, lacking systematic methods, and recycling utilization and exclusive sensing of UiO-66 still require further improvement. Therefore, one of the present research objectives is to explore the breakthrough point of existing technologies and optimize the performance of UiO-66-based electrochemical biosensors (UiO-66-EBs). In this work, we summarized current experimental methods and detection mechanisms of UiO-66-EBs in environmental detection, food safety, and disease diagnosis, analyzed the existing problems, and proposed some suggestions to provide new ideas for future research.

UiO-66-Derived PBA Composite as Multifunctional Electrochemical Non-Enzymatic Sensor Realizing High-Performance Detection of Hydrogen Peroxide and Glucose

“…Thus, as-obtained PBA nanocubes on the surface of UiO-66/NF contain Fe and Zr elements, which has been proven by EDS–elemental mapping of Fe and Zr in target PBA/UiO-66/NF as discussed in the previous section. As mentioned in the Introduction section, Zr with a high oxidation state has stronger coordination ability than the Fe element, which has been demonstrated by the previous literature . Herein, the contrast experiments between PBA/UiO-66/NF and PBA/NF we designed to provide more intuitive proof for explaining the improved stability upon introducing UiO-66.…”

“…As mentioned in the Introduction section, Zr with a high oxidation state has stronger coordination ability than the Fe element, which has been demonstrated by the previous literature. 20 Herein, the contrast experiments between PBA/UiO-66/NF and PBA/NF we designed to provide more intuitive proof for explaining the improved stability upon introducing UiO-66. UiO-66/NF electrode shows a significantly increased current response compared to initial PBA/UiO-66/NF, and contrasting NF, UiO-66/NF, and PBA/NF, indicating its effective electrocatalytic oxidation of glucose.…”

“…The strong Zr−O bond and high Zr(IV) coordination number in UiO-66 can result in good thermal and chemical stability. 20 Therefore, if UiO-66 can be introduced into the reaction system with the PBA material, an exciting result can be obtained. Except for that, UiO-66 itself is also an ideal sensing material because of its uniform pore size, large specific surface area, and high redox centers.…”

Capacitive Desalination and Disinfection of Water Using UiO-66 Metal–Organic Framework/Bamboo Carbon with Chitosan

“…The zirconium-based MOF material UiO-66 is composed of octahedral and tetrahedral cages and has excellent thermal, aqueous, and acid stability [ 27 , 28 , 29 ]. Based on these advantages, UiO-66 has been used as a catalytic carrier of precious metals to detect H 2 O 2 and telomerase [ 30 , 31 , 32 ]. However, research regarding UiO-66 and its composites used in the CDI desalination process is scarce.…”

A porous Ti-based metal–organic framework for CO2photoreduction and imidazole-dependent anhydrous proton conduction

“…9,10 The potential applications of these stable MOFs have been extensively explored. Among them, the frameworks based on UiO-66 are well studied, 11 due to the fact that UiO-66-based frameworks can serve as an excellent platform with great chemical and thermal stability (300–400 °C). For example, UiO-66-based frameworks are employed to evaluate their proton conductive behaviours in the presence of water.…”