Research progress on anti-ovarian cancer mechanism of miRNA regulating tumor microenvironment

Abstract

Ovarian cancer is the most deadly malignancy among women, but its complex pathogenesis is unknown. Most patients with ovarian cancer have a poor prognosis due to high recurrence rates and chemotherapy resistance as well as the lack of effective early diagnostic methods. The tumor microenvironment mainly includes extracellular matrix, CAFs, tumor angiogenesis and immune-associated cells. The interaction between tumor cells and TME plays a key role in tumorigenesis, progression, metastasis and treatment, affecting tumor progression. Therefore, it is significant to find new tumor biomarkers and therapeutic targets. MicroRNAs are non-coding RNAs that post-transcriptionally regulate the expression of target genes and affect a variety of biological processes. Studies have shown that miRNAs regulate tumor development by affecting TME. In this review, we summarize the mechanisms by which miRNAs affect ovarian cancer by regulating TME and highlight the key role of miRNAs in TME, which provides new targets and theoretical basis for ovarian cancer treatment.

Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

“…Serum-based biomarkers are considered the optimal Recent studies underscore the importance of placing greater emphasis on exosomal MicroRNA (miRNA), which is extensively implicated in the development of the epithelial ovarian cancer tumor microenvironment (EOC-TME). This emphasizes its crucial role in both the initiation and progression of tumors [30,31]. Several researchers have examined the expression profiles of miRNAs in serum samples from individuals with EOC, with the goal of identifying biomarkers for the condition [30,32].…”

“…This emphasizes its crucial role in both the initiation and progression of tumors [30,31]. Several researchers have examined the expression profiles of miRNAs in serum samples from individuals with EOC, with the goal of identifying biomarkers for the condition [30,32]. Although a specific study effectively identified certain circulating miRNAs consistently linked to epithelial ovarian cancer (EOC), there is a lack of consensus regarding the methodologies employed [32], and the costs associated with miRNA profiling are substantial [24].…”

lncRNA GAS5 suppression of the malignant phenotype of ovarian cancer via the miR-23a-WT1 axis

“…miRNA is a type of endogenous small noncoding RNA (sncRNA) comprising 18 25 nucleotides that regulates physiological functions including cellular growth, proliferation, and apoptosis ( 16 , 17 ). Several reports have revealed the significant involvement of miRNAs in various malignant processes of OC oncogenesis ( 18 , 19 ). In human malignancies, cross-modulation between miRNAs and lncRNAs has recently been found in multiple studies.…”