Research progress on anti-stress nutrition strategies in swine

Wang, Leli; Yao, Ping; Zhang, Yiru; Liu, Yuxin; Liu, Yan; Yin, Yulong

doi:10.1016/j.aninu.2023.03.006

Cited by 13 publications

(13 citation statements)

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“…Consequently, orientin was demonstrated to promote the transition of muscle fiber types from fast- to slow-twitch. Muscle fibers are classified based on their distinctive metabolic properties, and alterations in enzymatic activity associated with metabolism serve as indirect indicators of shifts in muscle fiber type. , Our findings demonstrate that orientin increases the activities of SDH and MDH in mouse genioglossus and C2C12 myotubes. These results lend credence to the role of orientin in muscle fiber type conversion.…”

Section: Discussionmentioning

confidence: 65%

Orientin Promotes Antioxidant Capacity, Mitochondrial Biogenesis, and Fiber Transformation in Skeletal Muscles through the AMPK Pathway

Liu,

Li,

Liu

et al. 2024

J. Agric. Food Chem.

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The sleep-breathing condition obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse, which can exacerbate oxidative stress and free radical generation, thereby detrimentally impacting both motor and sensory nerve function and inducing muscular damage. OSA development is promoted by increasing proportions of fast-twitch muscle fibers in the genioglossus. Orientin, a water-soluble dietary C-glycosyl flavonoid with antioxidant properties, increased the expression of slow myosin heavy chain (MyHC) and signaling factors associated with AMP-activated protein kinase (AMPK) activation both in vivo and in vitro. Inhibiting AMPK signaling diminished the effects of orientin on slow MyHC, fast MyHC, and Sirt1 expression. Overall, orientin enhanced type I muscle fibers in the genioglossus, enhanced antioxidant capacity, increased mitochondrial biogenesis through AMPK signaling, and ultimately improved fatigue resistance in C2C12 myotubes and mouse genioglossus. These findings suggest that orientin may contribute to upper airway stability in patients with OSA, potentially preventing airway collapse.

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Section: Discussionmentioning

confidence: 65%

Orientin Promotes Antioxidant Capacity, Mitochondrial Biogenesis, and Fiber Transformation in Skeletal Muscles through the AMPK Pathway

Liu,

Li,

Liu

et al. 2024

J. Agric. Food Chem.

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“…The gastrointestinal disturbances that appeared immediately after weaning resulted from changes in both the structure and functionality of the intestine. The weaning transition leads to profound changes in the histological features of the small intestine, affecting mainly the digestion and absorption processes [ 24 , 25 ]. For example, decreased villus height and increased crypt depth were observed in all segments of the small intestine [ 24 , 25 , 26 , 27 , 28 ].…”

Section: Weaning Transition In Piglets and The In-depth Mechanisms Of...mentioning

confidence: 99%

“…The weaning transition leads to profound changes in the histological features of the small intestine, affecting mainly the digestion and absorption processes [ 24 , 25 ]. For example, decreased villus height and increased crypt depth were observed in all segments of the small intestine [ 24 , 25 , 26 , 27 , 28 ]. Also, alterations in the intestinal permeability and a higher secretory activity were found in both the small intestine (jejunum) and in the colon of weaned piglets [ 29 , 30 ].…”

Section: Weaning Transition In Piglets and The In-depth Mechanisms Of...mentioning

confidence: 99%

“…For example, a decreased expression of occludin, CLDN-1 , ZO-1 , ZO-2 , and ZO-3 proteins and genes was detected in the jejunum and ileum of piglets [ 32 , 33 , 34 , 35 ]. This damage of the intestinal barrier is also due to a transient intestinal inflammation [ 36 ], the intestinal mucosa releasing pro-inflammatory mediators (e.g., interleukins—ILs—and tumor necrosis factor-α—TNF-α) [ 24 ]. In weaned piglets, an upregulation of TNF-α and interleukins (IL-1β, IL-6, IL-8, IL-10, IL-12α, IL-22) pro-inflammatory cytokines in the jejunum [ 37 , 38 ], ileum [ 39 ] and colon was registered [ 40 ].…”

Section: Weaning Transition In Piglets and The In-depth Mechanisms Of...mentioning

confidence: 99%

“…Recent studies have demonstrated that, in pigs, the most dominant phyla were Bacteroidetes , Firmicutes , Proteobacteria and Fusobacteria [ 61 , 62 , 63 , 64 , 65 ]. Post-weaning diarrhea was associated with an increased relative abundance of Prevotella , Campylobacter , Sutterella , Roseburia , Coprococcus , Dorea and Lachnospira and Fusobacteriaceae [ 24 , 62 , 66 ], while the relative abundances of Bacteroidaceae and Enterobacteriaceae , Bifidobacterium , Bacillus , Lactobacillus and Ruminococcus declined over the weaning period [ 60 , 66 , 67 , 68 ]. Li et al [ 61 ] observed a reduction in Alloprevotella and Oscillospira bacteria population in weaned piglets [ 61 ], with both species having positive effects on the gut barrier and anti-inflammatory roles [ 69 , 70 ], not only regarding bacteria distribution, but also the functional capacities of the microbial community, in terms of short-chain fatty acids’ (SCFAs) production [ 71 ].…”

Section: Weaning Transition In Piglets and The In-depth Mechanisms Of...mentioning

confidence: 99%

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The Use of Fruit and Vegetable by-Products as Enhancers of Health Status of Piglets after Weaning: The Role of Bioactive Compounds from Apple and Carrot Industrial Wastes

Pistol,

Pertea,

Taranu

2023

Veterinary Sciences

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At weaning, piglets are exposed to a large variety of stressors, from environmental/behavioral factors to nutritional stress. Weaning transition affects the gastrointestinal tract especially, resulting in specific disturbances at the level of intestinal morphology, barrier function and integrity, mucosal immunity and gut microbiota. All these alterations are associated with intestinal inflammation, oxidative stress and perturbation of intracellular signaling pathways. The nutritional management of the weaning period aims to achieve the reinforcement of intestinal integrity and functioning to positively modulate the intestinal immunity and that of the gut microbiota and to enhance the health status of piglets. That is why the current research is focused on the raw materials rich in phytochemicals which could positively modulate animal health. The composition analysis of fruit, vegetable and their by-products showed that identified phytochemicals could act as bioactive compounds, which can be used as modulators of weaning-induced disturbances in piglets. This review describes nutritional studies which investigated the effects of bioactive compounds derived from fruit (apple) and vegetables (carrot) or their by-products on the intestinal architecture and function, inflammatory processes and oxidative stress at the intestinal level. Data on the associated signaling pathways and on the microbiota modulation by bioactive compounds from these by-products are also presented.

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New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets

Zhang,

Chen,

Liu

et al. 2023

Animal Nutrition

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Research progress on anti-stress nutrition strategies in swine

Cited by 13 publications

References 342 publications

Orientin Promotes Antioxidant Capacity, Mitochondrial Biogenesis, and Fiber Transformation in Skeletal Muscles through the AMPK Pathway

Orientin Promotes Antioxidant Capacity, Mitochondrial Biogenesis, and Fiber Transformation in Skeletal Muscles through the AMPK Pathway

The Use of Fruit and Vegetable by-Products as Enhancers of Health Status of Piglets after Weaning: The Role of Bioactive Compounds from Apple and Carrot Industrial Wastes

New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets

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