Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone

Zegre, M.; Poljańska, E.; Caetano, L.A.; Gonçalves, L.; Bettencourt, A.

doi:10.1016/j.ijpharm.2023.123584

Cited by 5 publications

(2 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, its clinical application is restricted because to its elevated elastic modulus, intense heat generation during polymerization, and non-biodegradability. In addition, PMMA is biologically inert and exhibits unsatisfactory osseointegration characteristics [ 4 , 5 ]. Calcium phosphate bone cements (CPC) have attracted significant interest as synthetic substitutes for bone repair due to their chemical and structural resemblance to real bone, lack of toxicity, and good biocompatibility [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Nanofiber-induced hierarchically-porous magnesium phosphate bone cements accelerate bone regeneration by inhibiting Notch signaling

Chen,

Yu,

Gao

et al. 2024

Bioactive Materials

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Nanofiber-induced hierarchically-porous magnesium phosphate bone cements accelerate bone regeneration by inhibiting Notch signaling

Chen,

Yu,

Gao

et al. 2024

Bioactive Materials

View full text Add to dashboard Cite

“…To this end, various kinds of biomaterials loaded (or not) with different antimicrobial agents or antibiotics have been designed and developed to address the challenges during the OM treatment. The reported biomaterials included biodegradable metals [ 4 ], natural antimicrobial peptides-based biomaterials [ 5 ], biodegradable polymers [ 6 ], chitosan (CS) [ 7 ], hydrogels [ 8 ], nanoparticles (NPs) [ 9 ], nanohydroxyapatite/collagen granules [ 10 ], gelatin microspheres [ 11 ] and others. Among these options, hydrogels, especially those made from natural polymers, have shown great promise in OM treatment as essential attributes in biocompatibility, biodegradability, antibacterial drug loading and controlled release.…”

Section: Introductionmentioning

confidence: 99%

An injectable magnesium-coordinated phosphate chitosan-based hydrogel loaded with vancomycin for antibacterial and osteogenesis in the treatment of osteomyelitis

Zhang,

Wang,

Qian

et al. 2024

Regenerative Biomaterials

View full text Add to dashboard Cite

Microbial infections of bones, particularly after joint replacement surgery, are a common occurrence in clinical settings and often lead to osteomyelitis (OM). Unfortunately, current treatment approaches for OM are not satisfactory. To address this issue, this study focuses on the development and evaluation of an injectable magnesium oxide (MgO) nanoparticle-coordinated phosphocreatine-grafted chitosan hydrogel (CMPMg-VCM) loaded with varying amounts of vancomycin (VCM) for the treatment of OM. The results demonstrate that the loading of VCM does not affect the formation of the injectable hydrogel, and the MgO-incorporated hydrogel exhibits anti-swelling properties. The release of VCM from the hydrogel effectively kills staphylococcus aureus bacteria, with CMPMg-VCM (50) showing the highest antibacterial activity even after prolonged immersion in PBS solution for 12 days. Importantly, all the hydrogels are non-toxic to MC3T3-E1 cells and promote osteogenic differentiation through the early secretion of alkaline phosphatase and calcium nodule formation. Furthermore, in vivo experiments using a rat OM model reveal that the CMPMg-VCM hydrogel effectively kills and inhibits bacterial growth, while also protecting the infected bone from osteolysis. These beneficial properties are attributed to the burst release of VCM, which disrupts bacterial biofilm, as well as the release of Mg ions and hydroxyl by the degradation of MgO nanoparticles, which inhibits bacterial growth and prevents osteolysis. Overall, the CMPMg-VCM hydrogel exhibits promising potential for the treatment of microbial bone infections.

show abstract

Influence of alumina and PMMA on mechanical properties and aging behavior of 3D printed PLA composites: A comparative study

Nallamuthu,

Thirugnanasamabandam,

Kadirgama

et al. 2024

Polymer Composites

View full text Add to dashboard Cite

This study intends to investigate the mechanical, thermal, and aging behaviors of 3D‐printed PLA (polylactic acid)‐blend with 10% polymethyl methacrylate (PMMA) and 10% alumina polymer composites for biomedical applications using compressive, DSC, and DMA analysis. The experimental results revealed that aged PLA blend with alumina samples increased compressive strength by 60.1% and 37.8% during hydrolytic and enzymatic degradation, respectively, compared to aged PLA samples. Also, it was reported that the PLA blend with PMMA samples increased compressive strength by 51.1% and 24% after hydrolytic and enzymatic degradation, respectively, as compared to aged PLA samples. Furthermore, DSC analysis revealed that alumina blended samples had a higher Tg than pure PLA and PMMA blended samples. In addition, DMA investigation revealed that the Tg of aged neat PLA, PLA/PMMA, and PLA/alumina increased by 4.38%, 4.8%, and 4.6%, respectively, compared to unaged polymer composites. Additionally, PLA/alumina‐aged samples exhibited stronger aging properties than neat PLA and PLA/PMMA blended‐aged samples. It was reported that the weight loss of PLA/Alumina was lowered by 10.7% and 15.6% compared to aged PLA/PMMA samples, for hydrolytic and enzymatic aging respectively. It was found that PLA alumina has better mechanical, thermal, and degradation resistance than PLA materials.Highlights Alumina and PMMA materials were blended with PLA. Examined the aging and mechanical properties of PLA blended composites. Utilized hydrolytic and enzymatic aging for biomedical applications. Evaluated mechanical strength performance of aged and unaged samples. DSC and DMA were utlised for this research.

show abstract

Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone

Cited by 5 publications

References 85 publications

Nanofiber-induced hierarchically-porous magnesium phosphate bone cements accelerate bone regeneration by inhibiting Notch signaling

Nanofiber-induced hierarchically-porous magnesium phosphate bone cements accelerate bone regeneration by inhibiting Notch signaling

An injectable magnesium-coordinated phosphate chitosan-based hydrogel loaded with vancomycin for antibacterial and osteogenesis in the treatment of osteomyelitis

Influence of alumina and PMMA on mechanical properties and aging behavior of 3D printed PLA composites: A comparative study

Contact Info

Product

Resources

About