Research progress on carotenoid production by Rhodosporidium toruloides

Xie, Zhuo-Ting; Mi, Bing-Qian; Lu, Yong-Jun; Chen, Mou-Tong; Ye, Zhi-Wei

doi:10.1007/s00253-023-12943-0

Cited by 4 publications

(3 citation statements)

References 103 publications

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“…The authors showed an increase in the enzymatic activity of catalase and superoxide dismutase in the presence of the nanoparticles [67]. Studies have also showed that a low concentration of Cd 2+ (5.0 µmol/L) improves yeast growth, increasing the production of carotenoids [26]. R. mucilaginosa in the presence of Pb increased its growth and production of carotenes, specifically β-carotene [68].…”

Section: Heavy Metal Ions and Saltsmentioning

confidence: 95%

“…Substrates composed of sucrose and glucose are the most reported carbon sources in the bioproduction of carotenoids [25]. The carotenoid formation in this oleaginous yeast is stimulated in with a low C/N ratio; otherwise, a high C/N ratio causes higher lipid production than carotenoids [26]. In R. toruloides, when the C/N ratio increases, cell proliferation decreases due to the gradual depletion of the nitrogen source [27].…”

Section: Medium Compositionmentioning

confidence: 99%

“…Alkaline pH has been suggested to act as a stressor and alter metabolic rates and nutrient uptake, inducing glucose cellular metabolism and enhancing polysaccharide synthesis instead of carotenoids. Xie et al [26] proposed a strategy to increase carotenoids using two stages of fermentation with changes in pH: a first stage with a pH that favors growth and a second stage with a decrease in pH that stimulates the biosynthesis of carotenoids. The highest production of carotenoids in Rhodotorulas sp.…”

Section: The Phmentioning

confidence: 99%

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Current Advances in Carotenoid Production by Rhodotorula sp.

Ochoa-Viñals,

Alonso-Estrada,

Pacios-Michelena

et al. 2024

Fermentation

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Microbial carotenoids are pigments of lipophilic nature; they are considered promising substitutes for chemically synthesized carotenoids in the food industry. Their benefits for human health have been demonstrated due to their antioxidant capacity. Yeasts of the genus Rhodotorula have genotypic characteristics that allow them to accumulate high concentrations of carotenes under certain stress conditions. The present review includes recent information covering different aspects of carotenoid production in Rhodotorula sp. fermentation. This review focuses on fermentation carotenoid production strategies, describing various economic raw materials as sources of carbon and nitrogen, the capacity for tolerance to heavy metals, and the effect of light, pH, and salts on the accumulation of carotenoids. Genetic modification strategies used to obtain strains with increased carotenoid production are described. Furthermore, using magnetic nanoparticles in the fermentation system, which could be a stress factor that increases pigment production, is considered for the first time. Rhodotorula is a potential source of high-value carotenoids with applications in the cosmetics, pharmaceutical, and food industries.

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Section: Heavy Metal Ions and Saltsmentioning

confidence: 95%