Research progress on extraction, biological activities and delivery systems of natural astaxanthin

Zhao, Tong; Yan, Xiaojia; Sun, Lijun; Yang, Tianxin; Hu, Xin; He, Zhi‐Guo; Liu, Fuguo; Liu, Xuebo

doi:10.1016/j.tifs.2019.07.014

Cited by 128 publications

(68 citation statements)

References 58 publications

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“…Astaxanthin (3,3 -dihydroxy-β, β-carotene-4,4 -dione; C 40 H 5 2O 4 ) is a lipid-soluble oxycarotenoid widely used in food, aquaculture, nutraceutical, cosmetic and pharmaceutical industries due to its relatively high antioxidant activity compared with other antioxidant molecules. It has been reported that astaxanthin has 10 times the antioxidant activity of β-carotene, 60 times of coenzyme Q10, and 1000 times more antioxidant activity than vitamin E (Higuera-Ciapara et al, 2006;Shah et al, 2016;Zhao et al, 2019). Astaxanthin unique chemical structure makes it a powerful antioxidant with extraordinary biological and physiological properties including cardiovascular disease prevention, strengthening the immune system and anti-tumoral, anti-inflammatory, and anti-diabetes effects (Kurihara et al, 2002;Uchiyama et al, 2002;Ohgami et al, 2003;Pashkow et al, 2008;Nagendraprabhu and Sudhandiran, 2011;Peng et al, 2012;Fakhri et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Processes Triggered by PEF for Astaxanthin Extraction From Xanthophyllomyces dendrorhous

Aguilar-Machado

Delso

Martínez

et al. 2020

Front. Bioeng. Biotechnol.

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The aim of this study was to evaluate the potential of pulsed electric fields (PEF) to improve the extraction of the lipid-soluble astaxanthin from fresh biomass of a wild-type (CECT 11028) and mutant (ATCC 74219) Xanthophyllomyces dendrorhous strain using ethanol as solvent. Inactivation and propidium uptake studies revealed that inactivation is a good index for estimated the proportion of irreversible permeabilized cells when inactivation is higher than 70% in the two strains. Ethanol was ineffective for extracting carotenoids from the PEF-treated cells (20 kV/cm, 135 µs) of the two strains. However, after aqueous incubation of PEF-treated X. dendrorhous ATCC 74219 cells for 12 h, up to 2.4 ± 0.05 mg/g dried weight (d.w.) of carotenoids were extracted in ethanol. From total carotenoid extracted, around 84% corresponded to all-trans astaxanthin. The detection and quantification of esterase activity in the supernatant and the relationship between the percentage of esterase activity quantified and the amount of carotenoids extracted indicate that the extraction of astaxanthin was mediated by enzymatic esterase activity triggered by PEF during incubation. On the other hand, the formation of a large lipid globule into the cytoplasm of PEF-treated X. dendrorhous CECT 11028 cells during aqueous incubation prevented carotenoid extraction. The process developed in this investigation represents a more sustainable and greener method that those previously used for extracting astaxanthin from yeast.

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Section: Introductionmentioning

confidence: 99%

Enzymatic Processes Triggered by PEF for Astaxanthin Extraction From Xanthophyllomyces dendrorhous

Aguilar-Machado

Delso

Martínez

et al. 2020

Front. Bioeng. Biotechnol.

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“…The use of traditional solvent extraction has many disadvantages, such as large volumes of organic solvents, high extraction temperature, the risk of the thermal degradation of extracted molecules or the presence of solvent residues in the extracts [ 55 ]. Therefore, innovative extraction techniques are becoming more and more popular [ 56 , 57 , 58 ]. Among them, we can distinguish microwave-assisted extraction (MAE) [ 56 ], ultrasound-assisted extraction (UAE) [ 56 , 59 ], supercritical fluid extraction (SFE) [ 55 , 60 , 61 ] and enzyme-assisted extraction (EAE).…”

Section: Astaxanthin As a Valuable Biologically Active Compoundmentioning

confidence: 99%

“…Among them, we can distinguish microwave-assisted extraction (MAE) [ 56 ], ultrasound-assisted extraction (UAE) [ 56 , 59 ], supercritical fluid extraction (SFE) [ 55 , 60 , 61 ] and enzyme-assisted extraction (EAE). The main advantages of those methods are reduced solvent usage, short extraction time and higher extraction yield [ 58 ].…”

Section: Astaxanthin As a Valuable Biologically Active Compoundmentioning

confidence: 99%

Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications

2020

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Bioactive compounds of natural origin are gaining increasing popularity. High biological activity and bioavailability, beneficial effects on health and safety of use are some of their most desirable features. Low production and processing costs render them even more attractive. Microorganisms have been used in the food, medicinal, cosmetic and energy industries for years. Among them, microalgae have proved to be an invaluable source of beneficial compounds. Haematococcus pluvialis is known as the richest source of natural carotenoid called astaxanthin. In this paper, we focus on the cultivation methods of this green microalga, its chemical composition, extraction of astaxanthin and analysis of its antioxidant, anti-inflammatory, anti–diabetic and anticancer activities. H. pluvialis, as well as astaxanthin can be used not only for the treatment of human and animal diseases, but also as a valuable component of diet and feed.

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“…For example, micro-and nano-encapsulation in particles of different sizes and structure can improve astaxanthin stability, bioaccessibility, bioavailability, and bioactivity. These techniques were recently well-reviewed in the literature [34,35].…”

Section: Bioavailability and Metabolism Of Carotenoids And Astaxanthimentioning

confidence: 99%

Novel Insights into the Biotechnological Production of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its Industrial Use as Novel Food Ingredient

Jannel

Caro

Bermudes³

et al. 2020

JMSE

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Astaxanthin shows many biological activities. It has acquired a high economic potential and its current market is dominated by its synthetic form. However, due to the increase of the health and environmental concerns from consumers, natural forms are now preferred for human consumption. Haematococcus pluvialis is artificially cultured at an industrial scale to produce astaxanthin used as a dietary supplement. However, due to the high cost of its cultivation and its relatively low biomass and pigment productivities, the astaxanthin extracted from this microalga remains expensive and this has probably the consequence of slowing down its economic development in the lower added-value market such as food ingredient. In this review, we first aim to provide an overview of the chemical and biochemical properties of astaxanthin, as well as of its natural sources. We discuss its bioavailability, metabolism, and biological activities. We present a state-of-the-art of the biology and physiology of H. pluvialis, and highlight novel insights into the biotechnological processes which allow optimizing the biomass and astaxanthin productivities. We are trying to identify some lines of research that would improve the industrial sustainability and economic viability of this bio-production and to broaden the commercial potential of astaxanthin produced from H. pluvialis.

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Research progress on extraction, biological activities and delivery systems of natural astaxanthin

Cited by 128 publications

References 58 publications

Enzymatic Processes Triggered by PEF for Astaxanthin Extraction From Xanthophyllomyces dendrorhous

Enzymatic Processes Triggered by PEF for Astaxanthin Extraction From Xanthophyllomyces dendrorhous

Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications

Novel Insights into the Biotechnological Production of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its Industrial Use as Novel Food Ingredient

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