2021
DOI: 10.1007/s00253-021-11358-z
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Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer

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Cited by 30 publications
(22 citation statements)
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“…The exact mechanisms of gut microbes on clinical response are not well understood. Gut microflora could regulate cancer development through Inflammatory reaction, Immune reaction, specific protein activation, carcinogenic metabolite production (34). It's important that gut microbes have broader effects on immune cells, such as, dendritic cells (DCs), natural killer (NK) cell, and the subset of T cell (CD4 + T cell, CD8 + T cell or Th17 cells) in tumor microenvironment.…”
Section: Discussionmentioning
confidence: 99%
“…The exact mechanisms of gut microbes on clinical response are not well understood. Gut microflora could regulate cancer development through Inflammatory reaction, Immune reaction, specific protein activation, carcinogenic metabolite production (34). It's important that gut microbes have broader effects on immune cells, such as, dendritic cells (DCs), natural killer (NK) cell, and the subset of T cell (CD4 + T cell, CD8 + T cell or Th17 cells) in tumor microenvironment.…”
Section: Discussionmentioning
confidence: 99%
“…Overall, the above risk factors for esophageal cancer are well described in the literature in contrast to the gut microbiota which, may also play a role in carcinogenesis according to recent published studies ( Chen C et al., 2021 ; Zhou et al., 2021 ). Therefore, in this review, we briefly discussed the role of the gut microbiota in esophageal carcinogenesis and its alterations in esophageal cancer patients.…”
Section: Introductionmentioning
confidence: 94%
“…was found to be enriched to approx. 20% in the latter [32]. Presently, it is thought that unfavourable gut microbiota may promote cancer development by multiple mechanisms, e.g., immune response changes and carcinogenic metabolite production [33].…”
Section: Targeting the Gut Microbiome In Oncologymentioning
confidence: 99%