2022
DOI: 10.1039/d2ma00094f
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Research progress on nano-sensitizers for enhancing the effects of radiotherapy

Abstract: Radiotherapy (RT) is a local control of tumors using radiation, including external irradiation (EBRT) and internal irradiation (RIT). Cancer radiotherapy based on external beams is a major clinical treatment for...

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Cited by 22 publications
(19 citation statements)
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“…Furthermore, they found that sensitization mechanisms occurring through GNPs mostly follow the promotion of lethal complex damage, but SPION-DX repairable damage dominates. Other studies also reported the enhancement of radio-sensitization and synergistic effects on tumor cells in vitro and in vivo using X-rays accompanying with SPIONs and IONs [68][69][70]. Recently, in several studies, iron-based nanoparticle-mediated radio-sensitization was observed in combination with low-energy X-ray and monoenergetic γ-ray radiation [71][72][73].…”
Section: Iron-based Nanoparticlesmentioning
confidence: 97%
“…Furthermore, they found that sensitization mechanisms occurring through GNPs mostly follow the promotion of lethal complex damage, but SPION-DX repairable damage dominates. Other studies also reported the enhancement of radio-sensitization and synergistic effects on tumor cells in vitro and in vivo using X-rays accompanying with SPIONs and IONs [68][69][70]. Recently, in several studies, iron-based nanoparticle-mediated radio-sensitization was observed in combination with low-energy X-ray and monoenergetic γ-ray radiation [71][72][73].…”
Section: Iron-based Nanoparticlesmentioning
confidence: 97%
“…Unfortunately, due to the limited tolerance of normal tissues to radiation, high‐energy radiation inevitably causes some radiation damage to adjacent normal tissues within the beam path. [ 133 ] Therefore, in clinical practice, the choice of RT dose requires a trade‐off between tumor treatment effectiveness and radiation damage.…”
Section: Microbial‐enabled Photosynthetic Oxygenation For Enhanced Tu...mentioning
confidence: 99%
“…c) Volume growth curves of distal tumors in Balb/C mice at different time after different treatments. d) The volume growth curves of recurrent 4T1 tumors after different treatments at different time.Reproduced with permission [133]. Copyright 2022, Elsevier.…”
mentioning
confidence: 99%
“…Apart from these lanthanides, other dopants such as Er, Gd, Nd, and Dy [ 201 ] have been used with BaBPO 5 . Gul et al used Er, Gd, Nd as dopants, however no characteristic emission was studied.…”
Section: Mixed Anion Boratesmentioning
confidence: 99%