Research Progress on Natural Product Ingredients’ Therapeutic Effects on Parkinson’s Disease by Regulating Autophagy

Li, Sicong; Sun, Xu; Bi, Lei; Tong, Yujia; Liu, Xin

doi:10.1155/2021/5538200

Cited by 9 publications

(5 citation statements)

References 92 publications

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“…Although the essential role of dopamine on motor skill performance [37], an overabundance of intracellular dopamine has the potential to interact with α-synuclein neurons, leading to the induction of α-synuclein post-translational modification. The aforementioned process prompts the buildup of deleterious, dissolved α-synuclein oligomers, culminating in the degeneration of the nigrostriatal region and progressive motor impairment [38].…”

Section: Discussionmentioning

confidence: 99%

Effect of spermidine on long non‐coding RNAs MALAT1 in a rotenone induced‐rat model of Parkinson's disease

Badae,

Abdelmonsif,

Aly

et al. 2024

Fundamemntal Clinical Pharma

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BackgroundSpermidine is a natural biologically active substance that has widespread influences on the body.ObjectiveThis study aims to enhance our understanding of the potential effect of spermidine on long non‐coding RNA MALAT1 and explore the underlying mechanism in the rotenone‐induced rat model of Parkinson's disease.MethodsRats were sacrificed after locomotor behavioral testing. Striatal tissues were used to assess the expression of MALAT1, oxidative stress markers, and autophagy markers.ResultsOur study found that treatment with spermidine for 2 weeks during the induction of the model significantly improved behavioral assessment, dopamine levels, and attenuated the histopathological changes that occurred in PD in comparison to the non‐treated group.ConclusionOur preliminary study supports the protective effect of spermidine on the activation of autophagy and its antioxidant properties. Part of the antioxidant activity is due to the inhibition of MALAT1. However, MALAT1 does not correlate with the spermidine‐induced autophagy pathway.

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Section: Discussionmentioning

confidence: 99%

Effect of spermidine on long non‐coding RNAs MALAT1 in a rotenone induced‐rat model of Parkinson's disease

Badae,

Abdelmonsif,

Aly

et al. 2024

Fundamemntal Clinical Pharma

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“…However, drug repurposing can be challenging ( Keerie et al, 2021 ) and the identification of novel autophagy targets [such as ubiquitin ( Schmidt et al, 2021 )] and new drugs targeting this process is of utmost importance to use autophagy as a therapeutic tool in PD ( Stacchiotti and Corsetti, 2020 ; Wang Z.-Y. et al, 2021 ; Li et al, 2021 ). Supplementary Table S1 enlists the pharmaceutical modulators of autophagy discussed in this minireview.…”

Section: Discussionmentioning

confidence: 99%

Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s Disease

Sanchez-Mirasierra

Ghimire

Hernández-Díaz

et al. 2022

Front. Cell Dev. Biol.

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Macroautophagy, an evolutionary conserved catabolic process in the eukaryotic cell, regulates cellular homeostasis and plays a decisive role in self-engulfing proteins, protein aggregates, dysfunctional or damaged organelles, and invading pathogens. Growing evidence from in vivo and in vitro models shows that autophagy dysfunction plays decisive role in the pathogenesis of various neurodegenerative diseases, including Parkinson’s disease (PD). PD is an incurable and second most common neurodegenerative disease characterised by neurological and motor dysfunction accompanied of non-motor symptoms that can also reduce the life quality of patients. Despite the investment in research, the aetiology of the disease is still unknown and the therapies available are aimed mostly at ameliorating motor symptoms. Hence, therapeutics regulating the autophagy pathway might play an important role controlling the disease progression, reducing neuronal loss and even ameliorating non-motor symptoms. In this review, we highlight potential therapeutic opportunities involved in different targeting options like an initiation of autophagy, Leucine-rich repeat kinase 2 (LRRK2) inhibition, mitophagy, lysosomes, lipid metabolism, immune system, gene expression, biomarkers, and also non-pharmacological interventions. Thus, strategies to identify therapeutics targeting the pathways modulating autophagy might hold a future for therapy development against PD.

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“…Resveratrol is a polyphenolic compound derived from various plants that has antioxidant, antitumor, and anti-inflammatory effects, and it may be used to treat cardiovascular diseases ( Wang et al, 2006 ; Soylemez et al, 2008 ; Ingmer and Ingmer, 2019 ). Resveratrol regulates autophagy via a variety of pathways ( Jacqueline et al, 2021 ; Li et al, 2021 ; Sha et al, 2021 ). Autophagy plays an important role in the activation and proliferation of B cells.…”

Section: Traditional Chinese Medicine As An Autophagy Modulator For S...mentioning

confidence: 99%

Perturbed autophagy intervenes systemic lupus erythematosus by active ingredients of traditional Chinese medicine

Tian

Yuan²,

Huang³

et al. 2023

Front. Pharmacol.

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Systemic lupus erythematosus (SLE) is a common multisystem, multiorgan heterozygous autoimmune disease. The main pathological features of the disease are autoantibody production and immune complex deposition. Autophagy is an important mechanism to maintain cell homeostasis. Autophagy functional abnormalities lead to the accumulation of apoptosis and induce the autoantibodies that result in immune disorders. Therefore, improving autophagy may alleviate the development of SLE. For SLE, glucocorticoids or immunosuppressive agents are commonly used in clinical treatment, but long-term use of these drugs causes serious side effects in humans. Immunosuppressive agents are expensive. Traditional Chinese medicines (TCMs) are widely used for immune diseases due to their low toxicity and few side effects. Many recent studies found that TCM and its active ingredients affected the pathological development of SLE by regulating autophagy. This article explains how autophagy interferes with immune system homeostasis and participates in the occurrence and development of SLE. It also summarizes several studies on TCM-regulated autophagy intervention in SLE to generate new ideas for basic research, the development of novel medications, and the clinical treatment of SLE.

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Research Progress on Natural Product Ingredients’ Therapeutic Effects on Parkinson’s Disease by Regulating Autophagy

Cited by 9 publications

References 92 publications

Effect of spermidine on long non‐coding RNAs MALAT1 in a rotenone induced‐rat model of Parkinson's disease

Effect of spermidine on long non‐coding RNAs MALAT1 in a rotenone induced‐rat model of Parkinson's disease

Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s Disease

Perturbed autophagy intervenes systemic lupus erythematosus by active ingredients of traditional Chinese medicine

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