In order to obtain the influence of blade placement angle on the performance of plastic centrifugal pumps, this article used the velocity modulus method. Based on the method, the hydraulic design of the flow passage components of the plastic centrifugal pump was carried out, and the two-dimensional model and three-dimensional model diagram of the flow components were established. The flow field of the impeller model under different working conditions was simulated and the results were analyzed by ANSYS CFX. The influence of different fluid loads on the solid structure under design conditions on the structure characteristics of the impeller was studied by ANSYS Workbench. Impeller models with different outlet angles were established to study the influence of the outlet angle on the performance of pump, and fluid-structure interaction for different impeller models was utilized to study the influence of the outlet angle on the structural characteristics of the impeller. According to the Stepanoff velocity modulus method, considered the import prerotation, the wrap angle design method and the blade inlet angle design method were proposed. In order to study the influence of different inlet angles on the performance of pump, the inlet angle was changed to establish multiple sets of impeller models, 3D printing technology was used to print out each impeller, and performance experiments were performed on the pump equipped with the impeller. The result of the experiments showed that working pressure of plastic centrifugal pump exceeding 5âatm would cause impeller structure damage. When the outlet angle was 35°, the plastic centrifugal pump reached the highest efficiency of 81.0161% and the highest H of 35.8029. The maximum deformation caused by the flow field load on the impeller increased with the increase of the outlet angle. With the increase of the inlet angle, the efficiency and H of the plastic centrifugal pump were reduced. Under normal pressure load, the deformation of the impeller first decreased and then increased, and when ÎČ1 was 13°, the total deformation of the impeller was the smallest.