Research progress on the correlation between sacubitril-valsartan and cognitive function in hypertensive patients

Abstract

Sacubitril-valsartan can exert antihypertensive effects by blocking the effect of angiotensin Ⅱ and inhibiting the activity of enkephalinase. As a currently common antihypertensive drug, sacubitril-valsartan’s protective effects on target organs have been confirmed in more and more studies. Inhibition of enkephalinase can hinder the degradation and metabolism of beta-amyloid, deposition of which is a characteristic pathological feature of Alzheimer's disease. And hypertension itself is a risk factor for cognitive dysfunction, so long-term medications have the theoretical possibility to result in adverse effects on the cognitions of hypertensive patients. A review of various perspectives towards the effects of sacubitril-valsartan on cognitive function in patients with hypertension will be delivered.