Research Progress on the Mechanism and Management of Septic Cardiomyopathy: A Comprehensive Review

Pei, Xue-Bin; Liu, Bo

doi:10.1155/2023/8107336

Cited by 4 publications

(1 citation statement)

References 149 publications

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“…The treatment landscape for SCM carries significant implications, with current approaches predominantly focusing on supportive care, infection control, and hemodynamic support [ 5 , 45 - 46 ]. There is growing interest in therapeutic strategies targeting mitochondrial dysfunction in sepsis as a potential avenue for intervention [ 45 ].…”

Section: Reviewmentioning

confidence: 99%

Myocardial Injury as a Harbinger of Multi-organ Failure in Septic Shock: A Comprehensive Review

Singam

2024

Cureus

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Myocardial injury in the context of septic shock presents a multifaceted challenge in critical care medicine with implications for patient prognosis and therapeutic strategies. This comprehensive review explores the mechanisms, diagnostic approaches, and clinical implications of myocardial injury as a harbinger of multi-organ failure in septic shock. We delineate the pathophysiological processes underlying myocardial injury, including inflammation, oxidative stress, and microcirculatory dysfunction, and discuss the diagnostic utility of cardiac biomarkers and imaging modalities in identifying myocardial injury. Furthermore, we elucidate the prognostic significance of myocardial injury and its implications for patient management, highlighting the need for tailored therapeutic interventions to mitigate its adverse effects. Future research and clinical practice directions are also discussed, emphasizing the importance of personalized medicine approaches and multidisciplinary collaboration in optimizing outcomes for patients with septic shock-associated myocardial injury. This review aims to provide a comprehensive understanding of myocardial injury in septic shock and inform strategies for improving patient care in this challenging clinical scenario.

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Section: Reviewmentioning

confidence: 99%

Myocardial Injury as a Harbinger of Multi-organ Failure in Septic Shock: A Comprehensive Review

Singam

2024

Cureus

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Multiple-organ dysfunction in children with central nervous system infections

Ermolenko,

Pshenisnov,

Aleksandrovich

et al. 2024

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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BACKGROUND: Multiple-organ dysfunction syndrome is one of the most dangerous complications of critical illness in children, which helps determine the disease outcomes. AIM: This study aimed to examine the features of multiple-organ dysfunction syndrome in children with severe central nervous system (CNS) infection and identify factors that determine disease outcomes. MATERIALS AND METHODS: This single-center, retrospective, observational study enrolled 98 patients, which included 66 (67%) boys and 32 (33%) girls. The average age was 3.6 ± 2.5 years. The Glasgow coma scale (GCS) score was 8.8 ± 2.4 points. Shock was diagnosed in 43 (44%) patients. The average treatment duration in the intensive care unit (ICU) was 9.5 ± 6.2 days, the duration of mechanical ventilation was 6.0 ± 3.9 days, and the mortality rate was 9%. Depending on the outcome, the children were divided into groups I (recovery, n = 88) and II (death, n = 10). All indicators were recorded in the first 12 h from ICU admission. RESULTS: The most pronounced phenomena of cardiovascular dysfunction, such as decreased Teicholtz ejection fraction (62.3 L/min), were observed when the pSOFA scale score was 10 points, which was statistically significant when compared with the indicators in children with a pSOFA scale score of 8 points. In all patients, regardless of age, a negative correlation of moderate strength was found between the pSOFA scale score and the Teicholtz ejection fraction, and it was pronounced in children aged 7–17 years (R = –0.41; p = 0.008). A positive correlation was found between heart rate and pSOFA scale score in children aged 7–17 years (R = 0.72; p = 0.009). In the evaluation of the discriminatory ability of the pSOFA scale and Phoenix sepsis scores regarding the outcome on the first day of treatment in the ICU, the latter has greater prognostic significance (area under the curve, 0.866 vs 0.838; sensitivity, 76% vs 72%; specificity, 82% vs 79%). CONCLUSIONS: Low cardiac output syndrome and systemic hypoxia are key factors associated with fatal outcomes in children with severe CNS infections. The high clinical significance of the ejection fraction in predicting the outcomes of severe CNS infections in children, regardless of age, allows the use of this parameter for goal-oriented therapy.

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A mechanism study of tripartite motif 10 modulating septic cardiomyopathy

Yang,

2024

Cytojournal

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Objective: Septic cardiomyopathy (SCM), as a complication of the septic process, severely affects the myocardial function of patients, but its pathogenesis remains unclear. The article aims to explore the mechanism of tripartite motif 10 (TRIM10) in rats with SCM and provide animal experimental basis for the treatment and prevention of SCM. Material and Methods: An SCM rat model was constructed by intraperitoneal injection of lipopolysaccharide (LPS). Sh-NC and sh-TRIM10 groups were injected with sh-NC and sh-TRIM10 in the tail vein for 3 consecutive days before SCM modeling. The expression of TRIM10 was detected by Western blot and reverse transcription–polymerase chain reaction analyses. Hematoxylin–eosin staining was performed to observe pathological changes in myocardium. Cardiomyocyte apoptosis was detected by flow cytometry. Serum levels of cardiac troponin I, myohemoglobin, creatine kinase-MB, interleukin-18 (IL-18), interleukin-1 β (IL-1β), tumor necrosis factor-α (TNF-α), superoxide dismutase, and glutathione peroxidase (GSH-Px) were detected by enzyme-linked immunosorbent assay. Apoptosis-related proteins and toll-like receptor 4 (TLR4)/nuclear transcription factor-κB (NF-κB) pathway-related proteins were explored by Western blot assay. Results: TRIM10 expression increased in the LPS group (P < 0.0001). Myocardial tissue injury in SCM rats was improved after TRIM10 reduction compared with that in the LPS group. Knockdown of TRIM10 decreased the levels of MDA (P < 0.01), IL-18 (P < 0.0001), IL-1β (P < 0.0001), and TNF-α (P < 0.0001) and increased the contents of SOD (P < 0.001) and GSH-Px (P < 0.001) compared with those in the LPS group. TRIM10 reduced the apoptosis of H9C2 cells (P < 0.0001). After TRIM10 interference, the expression of p-P65/P65 (P < 0.0001) and TLR4 (P < 0.0001) was decreased. Conclusion: TRIM10 knockdown can reduce inflammation, oxidative stress, and apoptosis in SCM rats and has a protective effect on cardiomyocytes, which may be attributed to the regulation of the TLR4/NF-κB pathway.

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Research Progress on the Mechanism and Management of Septic Cardiomyopathy: A Comprehensive Review

Cited by 4 publications

References 149 publications

Myocardial Injury as a Harbinger of Multi-organ Failure in Septic Shock: A Comprehensive Review

Myocardial Injury as a Harbinger of Multi-organ Failure in Septic Shock: A Comprehensive Review

Multiple-organ dysfunction in children with central nervous system infections

A mechanism study of tripartite motif 10 modulating septic cardiomyopathy

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