Research progress on the pharmacological effects of matrine

Sun, Yuhan; Li, Xu; Cai, Qihan; Wang, Mengmeng; Wang, Xinliang; Wang, Siming; Ni, Zhiyu

doi:10.3389/fnins.2022.977374

Cited by 23 publications

(12 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavonoids, such as quercetin, apigenin, naringenin, fisetin and luteolin, mostly have anti-inflammatory, antibacterial, antiviral effects. 27 , 28 , 29 , 30 These effects are correspond to the “Pungent” can relieve exterior syndrome. Ricinine and atropine have central nervous system excitatory effect, 31 , 32 which emboding the inducing resuscitation effect of “Pungent”.…”

Section: Resultsmentioning

confidence: 99%

The characterization of traditional Chinese medicine natures and flavors using network pharmacology integrated strategy

Wang,

Wei,

Liu

et al. 2024

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

The characterization of traditional Chinese medicine natures and flavors using network pharmacology integrated strategy

Wang,

Wei,

Liu

et al. 2024

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

“…In patients with asthma, stimulated by a variety of factors, immune in asthma patients, stimulated by various factors, immune cells produce a large number of in ammatory factors such as TNF-α, IL-1β, IL-4, etc., and the synthesis and secretion of IFN-γ are reduced. [28,29] After antigenic stimulation, MCs release some chemicals such as histamine, β-aminohexosidase, LTB4, LTC4, LTE4, etc. Because their surface contains IgE high-a nity receptor FcεRI, BMMCs can be activated in vitro by corresponding antigen induction to simulate the sensitization and excitation phases of MC activation and degranulation in asthma, and can be used to study the various MC-related physiology, pathology, mechanism of drug action and other studies.In this study, we established an asthmatic cell model of BMMCs and detected the expression of Fyn, Lyn, Syk phosphorylated proteins and the levels of β-HEX, TNF-α, IL-6, LTC4 and Ca 2+ in different subgroups.…”

Section: Discussionmentioning

confidence: 99%

Effect of solasodine on mast cell-mediated OVA (ovalbumin)- induced airway inflammation in asthma via the Fyn-Lyn-Syk pathway

Guo,

Zhao,

Fang

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction: Current clinical asthma therapeutic drugs can produce a series of adverse effects when used for a long period of time or in high doses, so it is urgent to find new therapeutic strategies. Solasodine can inhibit ovalbumin (OVA)-induced type II inflammation in mice, but the mechanism is still unclear. Mast cell (MCs) degranulation is an important part of allergic reactions, and Src family kinases (SFKs) are involved in the activation of the initiation signal of MC degranulation, and Lyn, Fyn, and Syk among SFKs play important regulatory roles in MC degranulation. Regulation of SFKs can inhibit the MC degranulation process and suppress the occurrence of allergic reactions. Here, we explored the effects of solasodine on OVA-induced asthma in mice and MC-mediated allergic reactions. Methods: Mouse bone marrow-derived mast cells (BMMCs) cells were added with different concentrations (0, 2, 4, 6, 8,10, 12 and 14 µM) of solasodine to select the appropriate concentration. In transforming growth factor (TGF)-β1 treatment of BMMCs, cells were treated with 10 µM solasodine or dexamethasone (Dex), respectively, to analyze the possible mechanisms of action. A mouse model of bronchial asthma was constructed, and the mice were divided into control, OVA, OVA + Dex, OVA + solasodine (1 mg/kg) and OVA + solasodine (10 mg/kg) groups. The histopathological changes in the lungs of the mice were observed by staining with HE, Masson, and Tunel staining. ELISA assay was used to detect the differences between bronchoalveolar lavage fluid (BALF) and serum. IL-4, IL-5, IL-1β, TNF-α and LTD-4 levels were detected by ELISA. BALF inflammatory cells were detected by Wright staining and P-Fyn, P-Lyn and P-Syk protein expression in lung tissues were detected by Western blot. Results: In TGF-β1-induced BMMCs, solasodine significantly reduced the expression of P-Fyn, P-Lyn, and P-Syk, decreased the expression of cytokines IL-6, TNF-α, and LTC4 and calcium uptake, as well as inhibited mast cell degranulation. In ova mice, solasodine inhibited OVA-induced airway remodeling, production of IL-4, IL-5, IL-1β, TNF-α, and LTD-4, and degranulation of mast cells in asthmatic mice. Solasodine inhibited the activation of Fyn, Lyn, and Sky and reduced the number of inflammatory cells such as eosinophils, lymphocytes, and neutrophils in lung tissues of asthmatic mice. Conclusion: In this study, we found that solasodine could have a concentration-dependent therapeutic effect on OVA-induced allergic asthma, and solasodine could inhibit the release of mast cell degranulation signature mediator β-HEX and histamine, and the molecular mechanism of its efficacy might be related to its regulation of the intracellular calcium concentration and the IgE/FcεRI-mediated signaling pathways such as P-Fyn/Fyn, P-Lyn/Lyn, P-Syk/Syk, and etc.

show abstract

Section: Introductionmentioning

confidence: 99%

“…[4] Active components from S flavescens including picrasidine, oxymatrine, and flavonoids have been isolated and characterized by modern pharmacological studies, and are associated with antitumor, antiviral, anti-inflammatory, hepatoprotective, anti-arrhythmic, analgesic, antipyretic, antianaphylactic, and antiasthma properties. [5] Network pharmacology (NP) is a new paradigm that integrates network biology and pharmacology to systematically understand the mechanisms underlying the effect of drugs on complex disease networks. NP is based on the complex interactions between complex networks of disease-related genes and drug targets.…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology and molecular docking analyses of the potential target proteins and molecular mechanisms underlying the anti-arrhythmic effects of Sophora Flavescens

Zhai

Li²,

Q³

2023

Medicine

View full text Add to dashboard Cite

The objective was to investigate the potential cardiac arrhythmia-related target proteins and molecular mechanisms underlying the anti-arrhythmic effects of Sophora flavescens using network pharmacology and molecular docking. The bioactive ingredients and related target proteins of S flavescens obtained from the Traditional Chinese medicine systems pharmacology data platform, and gene names for target proteins were obtained from the UniProt database. Arrhythmia-related genes were identified by screening GeneCards and Online Mendelian inheritance in man databases. A Venn diagram was used to identify the key arrhythmia-related genes that are potentially targeted by the bioactive ingredients of S flavescens. Furthermore, CytoScape 3.7.2 software was used to construct an “ingredient-target” network diagram and the “drug-ingredient-target-disease” network diagram. We performed gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis in the Metascape database and performed the docking analysis using CB-Dock software. We identified 45 main bioactive ingredients, from S flavescens and 66 arrhythmia-related target proteins. Gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analysis showed that these targets were related to the chemical carcinogenesis-receptor activation signaling pathway, lipid and atherosclerosis signaling pathway, and fluid shear stress and atherosclerosis signaling pathway. Molecular docking showed that the target protein had good binding power with the main active components of the compound of S flavescens. Our study demonstrated the synergistic effects of multiple bioactive components of S flavescens on multiple arrhythmia-related target proteins and identified potential therapeutic mechanisms underlying the anti-arrhythmic effects of S flavescens, providing new clinical ideas for arrhythmia treatment.

show abstract

Research progress on the pharmacological effects of matrine

Cited by 23 publications

References 68 publications

The characterization of traditional Chinese medicine natures and flavors using network pharmacology integrated strategy

The characterization of traditional Chinese medicine natures and flavors using network pharmacology integrated strategy

Effect of solasodine on mast cell-mediated OVA (ovalbumin)- induced airway inflammation in asthma via the Fyn-Lyn-Syk pathway

Network pharmacology and molecular docking analyses of the potential target proteins and molecular mechanisms underlying the anti-arrhythmic effects of Sophora Flavescens

Contact Info

Product

Resources

About