Research progress on the regulatory role of cell membrane surface tension in cell behavior

Li, Manqing; Xing, Xiumei; Yuan, Jianhui; Zeng, Zhuoying

doi:10.1016/j.heliyon.2024.e29923

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e29923

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Research progress on the regulatory role of cell membrane surface tension in cell behavior

Manqing Li,

Xiumei Xing,

Jianhui Yuan

et al.

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2024

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Cited by 1 publication

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New Family of Benzimidazole-Based Chitosan Derivatives against Penicillium expansum

Lv,

Liu,

Zhang

et al. 2024

J. Agric. Food Chem.

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Penicillium expansum is the major fungus that causes blue mold and produces patulin, threatening human health. Due to health and environmental pollution concerns, chitosan (CS) has attracted more and more attention as a safer alternative to synthetic fungicides for the control of blue mold. In the present study, four different benzimidazole groups were introduced onto CS by the acylation reaction to obtain benzimidazole-based chitosan derivatives (R1b−R4b). After being well-characterized with Fourier transform infrared spectroscopy (FTIR), ultraviolet−visible spectroscopy (UV−vis spectra), and nuclear magnetic resonance (NMR), their antifungal activities against P. expansum were screened. Results showed that the inhibitory effects of chitosan derivatives against the pathogen were significantly correlated with chitosan derivatives' concentration and their structures. R4b was shown as optimum with good solubility and antifungal activity with a minimum inhibitory concentration (MIC) value of 0.5 mg/mL and a minimum fungicidal concentration (MFC) value of 2.0 mg/mL. The remarkable antifungal efficiency of R4b against P. expansum was further demonstrated in terms of spore germination, mycelial growth, patulin production, and the preliminary antifungal mechanism. R4b exhibited significant inhibition of patulin production, while its antifungal mechanism was revealed by destroying cell membrane integrity and inducing membrane depolarization. Furthermore, R4b treatment could significantly reduce the incidence of blue mold rot in apple fruit, and the MTT assay showed the nontoxicity of R4b against Raw 264.7, HBZY-1, and Caco-2 cells. Altogether, these results indicate that it is promising to be used as a fruit preservative in the future.

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New Family of Benzimidazole-Based Chitosan Derivatives against Penicillium expansum

Lv,

Liu,

Zhang

et al. 2024

J. Agric. Food Chem.

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show abstract

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Research progress on the regulatory role of cell membrane surface tension in cell behavior

Cited by 1 publication

References 173 publications

New Family of Benzimidazole-Based Chitosan Derivatives against Penicillium expansum

New Family of Benzimidazole-Based Chitosan Derivatives against Penicillium expansum

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