Research progress on three different types of noncoding RNAs related to ionizing radiation

Gao, Jin; Zong, Xumin; Chen, Na; Lan, Tingxi; Yu, Wentao; Long, Huiqiang; Cui, Fengmei; Yu, Ting

doi:10.1016/j.radmp.2021.04.001

Cited by 2 publications

(2 citation statements)

References 45 publications

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“…One of the most notable advances in understanding the role of non-coding RNAs in IR-induced cancer has been their detection in exosomes from irradiated cells [ 33 ]. Among the various classes of non-coding RNA, long non-coding RNA (lncRNA), microRNA (miRNA) and circular RNA have been studied the most in IR-induced carcinogenesis [ 34 , 35 ]. Because of distinct changes in their expression upon radiation exposure, and due to their stability and abundance in serum and other biofluids, several of these non-coding RNAs have been proposed as diagnostic and prognostic biomarkers of radiation damage.…”

Section: Methodsmentioning

confidence: 99%

Ionizing radiation-induced cancer: perplexities of the bystander effect

Gopinathan¹,

Gopinathan²

2023

ecancer

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Ionizing radiation (IR) is a carcinogen. This has been established beyond doubt from many years of studies such as those conducted among the survivors of the atomic bomb attacks on Hiroshima and Nagasaki and later from the Chernobyl accident. Despite immense progress in the field of carcinogenesis, complete understanding of the underlying mechanisms behind IR-induced cancer remains elusive. In particular, the long gestation period between exposure to IR and the onset of cancer, frequently unpredictable, and sometimes lasting for many years, remains poorly understood. The centrality of DNA damage and misrepair in carcinogenesis research has not entirely benefited IR-induced cancer research and the past decade has seen a shift in understanding radiation-driven cellular mechanisms beyond simplistic models of targeted DNA damage. This paper presents a viewpoint on the gaps in our knowledge of IR-induced cancer with a focus on the non-targeted bystander effect, the mechanisms underlying which may be key to radiotherapeutic advances.

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Section: Methodsmentioning

confidence: 99%

Ionizing radiation-induced cancer: perplexities of the bystander effect

Gopinathan¹,

Gopinathan²

2023

ecancer

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“…Recently, RNAs have been identified as important players in the cellular response to ionizing radiation (IR), particularly by affecting the deoxyribonucleic acid (DNA) damage response ( 6 ). Involvement has been documented for several lncRNAs in response to high doses of IR (HDIR, ≥ 2Gy) ( 7 ) as well as low doses of IR (LDIR, ≤ 0.5Gy, ( 8 )). lncRNAs can directly act as part of the damage response by binding repair factors at the site of a radiation-induced double-strand break or indirectly by regulating the cell cycle, transcription and/or translation, as well as working of miRNAs through acting as miRNA sponges ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls

et al. 2023

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IntroductionLong non-coding ribonucleic acids (lncRNAs) are involved in the cellular damage response following exposure to ionizing radiation as applied in radiotherapy. However, the role of lncRNAs in radiation response concerning intrinsic susceptibility to late effects of radiation exposure has not been examined in general or in long-term survivors of childhood cancer with and without potentially radiotherapy-related second primary cancers, in particular.MethodsPrimary skin fibroblasts (n=52 each) of long-term childhood cancer survivors with a first primary cancer only (N1), at least one second primary neoplasm (N2+), as well as tumor-free controls (N0) from the KiKme case-control study were matched by sex, age, and additionally by year of diagnosis and entity of the first primary cancer. Fibroblasts were exposed to 0.05 and 2 Gray (Gy) X-rays. Differentially expressed lncRNAs were identified with and without interaction terms for donor group and dose. Weighted co-expression networks of lncRNA and mRNA were constructed using WGCNA. Resulting gene sets (modules) were correlated to the radiation doses and analyzed for biological function.ResultsAfter irradiation with 0.05Gy, few lncRNAs were differentially expressed (N0: AC004801.4; N1: PCCA-DT, AF129075.3, LINC00691, AL158206.1; N2+: LINC02315). In reaction to 2 Gy, the number of differentially expressed lncRNAs was higher (N0: 152, N1: 169, N2+: 146). After 2 Gy, AL109976.1 and AL158206.1 were prominently upregulated in all donor groups. The co-expression analysis identified two modules containing lncRNAs that were associated with 2 Gy (module1: 102 mRNAs and 4 lncRNAs: AL158206.1, AL109976.1, AC092171.5, TYMSOS, associated with p53-mediated reaction to DNA damage; module2: 390 mRNAs, 7 lncRNAs: AC004943.2, AC012073.1, AC026401.3, AC092718.4, MIR31HG, STXBP5-AS1, TMPO-AS1, associated with cell cycle regulation).DiscussionFor the first time, we identified the lncRNAs AL158206.1 and AL109976.1 as involved in the radiation response in primary fibroblasts by differential expression analysis. The co-expression analysis revealed a role of these lncRNAs in the DNA damage response and cell cycle regulation post-IR. These transcripts may be targets in cancer therapy against radiosensitivity, as well as provide grounds for the identification of at-risk patients for immediate adverse reactions in healthy tissues. With this work we deliver a broad basis and new leads for the examination of lncRNAs in the radiation response.

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Research progress on three different types of noncoding RNAs related to ionizing radiation

Cited by 2 publications

References 45 publications

Ionizing radiation-induced cancer: perplexities of the bystander effect

Ionizing radiation-induced cancer: perplexities of the bystander effect

Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls

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