Research progress regarding the role of long non‑coding RNAs in osteosarcoma (Review)

Pu, Yanchuan; Wang, Jin; Li, Zi‐Cai; Wang, Hulin

doi:10.3892/ol.2020.11807

Cited by 14 publications

(12 citation statements)

References 74 publications

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“…It is involved in histone modification, chromatin remodeling, DNA methylation, and gene activation or silencing [ 8 ]. At present, the role of lncRNA in the occurrence and metastasis of osteosarcoma has not been elucidated [ 9 ]. Transcriptome sequencing technology is widely used in the screening of tumor-related lncRNA expression profiles.…”

Section: Introductionmentioning

confidence: 99%

LncRNA LOC100129620 promotes osteosarcoma progression through regulating CDK6 expression, tumor angiogenesis, and macrophage polarization

Chen

Tang

Qian

et al. 2021

Aging

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Osteosarcoma is a malignant tumor with high mortality in children and adolescents. The mechanism of osteosarcoma metastasis is currently unclear. Abnormal expression of long non-coding RNA (lncRNA) plays an important role in tumor metastasis. We used bioinformatics to analyze the differences in gene expression between osteosarcoma in situ and osteosarcoma lung metastases. CCK-8 was used to detect the effect of lncRNA LOC100129620 on the proliferation of osteosarcoma cells. The effect of LOC100129620 on the invasion of osteosarcoma cells was assessed by Transwell assay. The regulatory effect of LOC100129620 on miR-335-3p was examined using RNA pull-down and luciferase reporter gene assays. The effect of LOC100129620 on the polarization of macrophages was detected by quantitative real-time fluorescent PCR. The results show that LOC100129620 can promote the proliferation and migration of osteosarcoma cells. LOC100129620 can promote the proliferation of osteosarcoma in vivo . LOC100129620 can bind to miR-335-3p and regulate its function. MiR-335-3p mediates the regulatory effects of LOC100129620 on CDK6. LOC100129620 promotes the formation of blood vessels and the polarization of macrophages. The LOC100129620/miR-335-3p/CDK6 signaling pathway promotes the metastasis of osteosarcoma by regulating the proliferation of osteosarcoma cells, angiogenesis, and macrophage polarization.

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Section: Introductionmentioning

confidence: 99%

LncRNA LOC100129620 promotes osteosarcoma progression through regulating CDK6 expression, tumor angiogenesis, and macrophage polarization

Chen

Tang

Qian

et al. 2021

Aging

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“…In addition, lncRNAs act in the ceRNA system to impact the lncRNAs-miRNAs interaction. More detailed mechanisms are involved in two recently-published reviews by Zhang et al and Han et al [ 1 , 33 ]. There are several papers concerning roles of lncRNAs or Wnt/β-catenin pathway in osteosarcoma or crosstalk between lncRNAs and Wnt pathway with a few depictions of the intersection among these three [ 1 , 6 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Lin

Liu

et al. 2021

Cancer Cell Int

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Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play crucial functions in initiation, progression, therapeutic resistance, recurrence and metastasis of tumor. Considerable studies revealed a dysregulated lncRNA expression pattern in osteosarcoma, which may act as oncogenes or suppressors to regulate osteosarcoma progression. Wnt signaling pathway is an important cascade in tumorigenesis by modulation of pleiotropic biological functions including cell proliferation, apoptosis, differentiation, stemness, genetic stability and chemoresistance. Hyperactivation or deficiency of key effectors in Wnt cascade is a common event in many osteosarcoma patients. Recently, increasing evidences have suggested that lncRNAs could interplay with component of Wnt pathway, and thereby contribute to osteosarcoma onset, progression and dissemination. In this review, we briefly summarize Wnt signaling-related lncRNAs in osteosarcoma progression, aiming to gain insights into their underlying crosstalk as well as clinical application in osteosarcoma therapeutic modalities.

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“…10 Changes in lncRNA expression have been frequently observed in patients with OS, in which lncRNAs function as tumor promoters or inhibitors to control a variety of malignant processes. 11,12 miRNAs are a set of highly conserved, single-stranded, and noncoding RNA transcripts that are 18-24 nucleotides in length. 13 They can modulate gene expression at the post-transcriptional level by directly binding to the 3′untranslated regions (3ʹ-UTRs) of their target mRNAs and triggering translational repression or mRNA impairment.…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA CCDC144NL-AS1 Promotes the Oncogenicity of Osteosarcoma by Acting as a Molecular Sponge for microRNA-490-3p and Thereby Increasing HMGA2 Expression

Guan

Liao

et al. 2021

OTT

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Research progress regarding the role of long non‑coding RNAs in osteosarcoma (Review)

Cited by 14 publications

References 74 publications

LncRNA LOC100129620 promotes osteosarcoma progression through regulating CDK6 expression, tumor angiogenesis, and macrophage polarization

LncRNA LOC100129620 promotes osteosarcoma progression through regulating CDK6 expression, tumor angiogenesis, and macrophage polarization

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Long Noncoding RNA CCDC144NL-AS1 Promotes the Oncogenicity of Osteosarcoma by Acting as a Molecular Sponge for microRNA-490-3p and Thereby Increasing HMGA2 Expression

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