Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits

Abstract

Animals are valuable resources in biomedical research in investigations of biological processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and carcinogenicity. Interpretation of data from animals requires knowledge not only of the processes or diseases (pathophysiology) under study but also recognition of spontaneous conditions and background lesions (pathology) that can influence or confound the study results. Species, strain/stock, sex, age, anatomy, physiology, spontaneous diseases (noninfectious and infectious), and neoplasia impact experimental results and interpretation as well as animal welfare. This review and the references selected aim to provide a pathology resource for researchers, pathologists, and veterinary personnel who strive to achieve research rigor and validity and must understand the spectrum of “normal” and expected conditions to accurately identify research-relevant experimental phenotypes as well as unusual illness, pathology, or other conditions that can compromise studies involving laboratory mice, rats, gerbils, guinea pigs, hamsters, naked mole rats, and rabbits.

CARCINOMA POUCO DIFERENCIADO ULCERADO E INVASIVO EM ESQUILODA-MONGÓLIA (Meriones unguiculatus) – RELATO DE CASO

“…Em suma, devido a ocorrência de neoplasias na glândula do cheiro ser frequente, a realização da excisão cirúrgica do nódulo e da glândula é recomendada, além da diferenciação entre neoplasias benignas ou metastática, visto que a última pode se disseminar, afetando linfonodos ou pulmões (PESSOA et al, 2010;DEUTSCHLAND et al, 2011;COOPER et al, 2021;QUESENBERRY et al, 2021). Diante disso, o tratamento de escolha no relato descrito consistiu na excisão com margem segura do nódulo e da glândula de cheiro devido ao fator de disseminação da neoplasia para outros locais do organismo, posteriormente sendo executado técnica de dermorrafia e associação com curativo visando o melhor controle da ferida cirúrgica e cicatrização da região ventral, sendo possível proporcionar total resolução e melhora do quadro clínico, consequentemente apresentando um prognóstico favorável para a qualidade de vida do paciente.…”

Standardization of Animal Models and Techniques for Platelet-Rich Fibrin Production: A Narrative Review and Guideline

“…The coagulation time for rabbit blood is around 5 to 10 min, which is similar to the coagulation time in humans. In addition, they are often considered the best animal model to study human platelets due to their similarities in platelet function and regulation [ 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 ]. Regarding platelet count, rabbits have a similar range of platelet numbers compared to humans, with an average platelet count ranging from 150,000 to 450,000 platelets per microliter of blood.…”

Phytotherapeutische und regulationsmedizinische Behandlung von Verdauungsproblemen bei Meerschweinchen und Kaninchen – von den Pferden lernen

“…© otsphoto/stock.adobe.com Zähne, Gebiss, Kiefer Ein häufiger Konsultationsgrund sind die Zähne bzw. das Gebiss der Heimtiere [1]. Das Gleichgewicht zwischen ständigem Wachstum der Zähne und deren Abrieb durch ausreichend Strukturfutter gerät vielfach aus dem Lot.…”