Research revealed a targeted regulatory relationship between hsa-mir-296 or hsa-mir-744 and TNSF15 in colorectal cancer

Abstract

BACKGROUD: Colorectal cancer has an extremely high incidence and mortality rate, and early detection and treatment is important for health. METHODS: DEmiRNAs were searched for in different datasets. core DEmiRNAs were identified by one-factor cox analysis and target genes were predicted using targetscan and miRDB. Select intersections of target genes and DEmRNAs to identify key genes by survival analysis. RESULTS: Three miRNAs in COAD and two miRNAs in READ were identified as core DEmiRNAs. After searching for targeted mRNA and conducting survival and expression analysis, it was found that hsa-mir-296-TNSF15 and hsa-mir-744-TNSF15 are effective regulatory networks in colorectal cancer. CONCLUSION: This study identified hsa-mir-296-TNSF15 and hsa-mir-744-TNSF15 as effective regulatory networks related to the prognosis of colorectal cancer.