Traditional nonintrusive object inspection methods are complex or extremely expensive to apply in certain cases, such as inspection of enormous objects, underwater or maritime inspection, an unobtrusive inspection of a crowded place, etc. With the latest advances in robotics, autonomous self-driving vehicles could be applied for this task. The present study is devoted to a review of the existing and novel technologies and methods of using autonomous self-driving vehicles for nonintrusive object inspection. Both terrestrial and maritime self-driving vehicles, their typical construction, sets of sensors, and software algorithms used for implementing self-driving motion were analyzed. The standard types of sensors used for nonintrusive object inspection in security checks at the control points, which could be successfully implemented at self-driving vehicles, along with typical areas of implementation of such vehicles, were reviewed, analyzed, and classified.