Aqueous zinc‐ion batteries (AZIBs) are garnering substantial research interest in electric vehicles, energy storage systems, and portable electronics, primarily for the reason that the inexpensive cost, high theoretical specific capacity, and environmental sustainability of zinc metal anodes, which are an essential component to their design. Nonetheless, the progress of AZIBs is hindered by significant obstacles, such as the occurrence of anodic side reactions (SR) and the formation of zinc dendrites. Metal‐organic framework (MOF)‐based materials are being explored as promising alternatives owing to homogeneous porous structure and large specific surface areas. There has been a rare overview and discussion on strategies for protecting anodes using MOF‐based materials. This review specifically aims to investigate cutting‐edge strategies for the design of highly stable MOF‐based anodes in AZIBs. Firstly, the mechanisms of dendrites and SR are summarized. Secondly, the recent advances in MOF‐based anodic protection including those of pristine MOFs, MOF composites, and MOF derivatives are reviewed. Furthermore, the strategies involving MOF‐based materials for zinc anode stabilization are presented, including the engineering of surface coatings, three‐dimensional zinc structures, artificial solid electrolyte interfaces, separators, and electrolytes. Finally, the ongoing challenges and prospective directions for further enhancement of MOF‐based anodic protection technologies in AZIBs are highlighted