This study investigates the impact of varying side wind velocities and nozzle inclination angles on droplet penetration during plant protection spraying operations, focusing on citrus trees. Experiments were conducted across four wind speed levels (0, 1, 2, 3 m/s) perpendicular to the nozzle direction and seven nozzle inclination levels (0°, 8°, 15°, 23°, 30°, 38°, 45°) to evaluate droplet distribution under different spraying parameters. A baseline condition with 0 m/s wind speed and a 0° nozzle angle served as the control. Utilizing Computational Fluid Dynamics (CFD) and regression analysis techniques in conjunction with field trials, the droplet penetration was analyzed. Results indicate that at constant wind speeds, adjusting the nozzle inclination angle against the direction of the side wind can significantly enhance droplet deposition in the canopy, with a 23° inclination providing the optimal increase in deposition volume, averaging a change of +16.705 μL/cm2. Multivariate nonlinear regression analysis revealed that both wind speed and nozzle inclination angle significantly affect the droplet penetration ratio, demonstrating a correlation between these factors, with wind speed exerting a greater impact than nozzle angle. Increasing the nozzle inclination angle at higher wind speeds improves the penetration ratio, with the optimal parameters being a 23° angle and 3 m/s wind speed, showing a 12.6% improvement over the control. The model fitted for the impact of nozzle angle and wind speed on droplet penetration was validated through field experiments, identifying optimal angles for enhancing penetration at wind speeds of 1, 2, and 3 m/s as 8°, 17°, and 25°, respectively. This research provides insights for improving droplet penetration techniques in plant protection operations.