With the rapid development of the Internet of Things (IoT), the logistics and transportation industry is booming. At the same time, with the advancement of AI technology, intelligent logistics is also gradually emerging, and the purpose of intelligent logistics is to use different types of automatic guided transport machines to replace people to handle and move products. At the same time, with the help of big data, cloud computing, artificial intelligence, sensor technology, and other technologies, we can achieve logistics automation. However, the current logistics robot creation platforms are diverse, which makes intelligent logistics robots diverse in variety and wide in application and also makes the creation and use of robots more challenging. Robot Operating System (ROS) is an open-source software platform that supports programming in multiple languages and has excellent adaptability. In addition, most of the currently used path planning focuses on a single target point, which is insufficient to support the current needs of multitasking in intelligent logistics. Therefore, this paper aimed to design an intelligent logistics management system based on ROS robot and proposed to use the A-star algorithm to calculate the shortest path of the robot so as to achieve the optimal path. In the simulation experiment, 20 ROS robots were selected and divided into two groups. In the logistics warehouse of different transportation nodes, 20 ROS robots were set up to transport goods of different weights in the experiment, and the transportation data were collected at last. The final simulation results have shown that the power consumption and response delay performance of the ROS robot are good, and the logistics transportation speed is significantly improved. In addition, compared with the traditional transportation method, the daily transportation weight of each robot is up to 310.1% and the monthly profit is up to 171%, which shows that the intelligent logistics management system designed in this paper is more efficient in logistics and transportation and can bring more profits.