Research trends in Caenorhabditis elegans and aging from 2004 to 2023: a bibliometric analysis.

Abstract

Caenorhabditis elegans (C. elegans) have emerged as a prominent model organism for investigating aging, owing to its short life cycle, complete body transparency, protein editing capabilities, and advancements in aging-related pathways. Despite the significance of C. elegans in aging research, there is currently a lack of bibliometric analysis on this topic. To address this gap and gain deeper insights into C. elegans and aging, we retrieved 6204 records from the Web of Science database and employed scientometric tools such as CiteSpace and VOSviewer software to conduct an extensive analysis encompassing countries/regions, institutions, authors, journals, co-cited literature, and keywords. This study aims to provide a comprehensive assessment of research trends in the field of C. elegans and aging using bibliometric approaches while also identifying potential avenues for future investigations. Currently, key areas within C. elegans and aging research primarily revolve around dauer larvae、caloric restriction、stress resistance and alzheimers disease pathogenesis exploration. It is noteworthy that insulin, anti-aging, free radicals, neurodegeneration, and antioxidants have emerged as the most prominent and rapidly advancing frontiers in current research. We anticipate that this study will contribute to the advancement of scientific research in C. elegans and aging, while facilitating potential collaborations and fostering interdisciplinary partnerships for scientists and scholars.