Researches on cognitive sequelae of burn injury: Current status and advances

Xie, Chen-chen; Hu, Jun; Cheng, Yong; Yao, Zhong-Xiang

doi:10.3389/fnins.2022.1026152

Cited by 7 publications

(4 citation statements)

References 135 publications

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“…The upregulation of multiple proinflammatory mediators alongside the onset, development, and progression of burn injuries, further, gives rise to an aberrant inflammation at the site of a burn injury [ 98 ]. Therefore, severe burn injuries can result in various disorders, such as sepsis, skeletal muscle dysfunction, and cognitive sequelae [ 98 , 99 , 100 ]. Accumulative evidence indicates that the SP–NK1R system is an important contributor to burn injury-induced inflammation and subsequent remote lung injury [ 69 ].…”

Section: Substance P and Its Receptors In Inflammation-associated Org...mentioning

confidence: 99%

Inflammation and Organ Injury the Role of Substance P and Its Receptors

Zhu

Bhatia

2023

IJMS

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Tightly controlled inflammation is an indispensable mechanism in the maintenance of cellular and organismal homeostasis in living organisms. However, aberrant inflammation is detrimental and has been suggested as a key contributor to organ injury with different etiologies. Substance P (SP) is a neuropeptide with a robust effect on inflammation. The proinflammatory effects of SP are achieved by activating its functional receptors, namely the neurokinin 1 receptor (NK1R) receptor and mas-related G protein-coupled receptors X member 2 (MRGPRX2) and its murine homolog MRGPRB2. Upon activation, the receptors further signal to several cellular signaling pathways involved in the onset, development, and progression of inflammation. Therefore, excessive SP–NK1R or SP–MRGPRX2/B2 signals have been implicated in the pathogenesis of inflammation-associated organ injury. In this review, we summarize our current knowledge of SP and its receptors and the emerging roles of the SP–NK1R system and the SP–MRGPRX2/B2 system in inflammation and injury in multiple organs resulting from different pathologies. We also briefly discuss the prospect of developing a therapeutic strategy for inflammatory organ injury by disrupting the proinflammatory actions of SP via pharmacological intervention.

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Section: Substance P and Its Receptors In Inflammation-associated Org...mentioning

confidence: 99%

Inflammation and Organ Injury the Role of Substance P and Its Receptors

Zhu

Bhatia

2023

IJMS

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“…In addition, burns can cause scarring, deformity, and dysfunction, all of which may have long-term effects on the patient’s physical and mental health [ 1 ]. Burns also cause neurological cognitive dysfunction, including memory deficits, amnesia, dementia, depression, anxiety, post-traumatic stress disorder (PTSD), hallucinations and delirium [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

In silico analysis of intestinal microbial instability and symptomatic markers in mice during the acute phase of severe burns

Hou,

Zhang,

Zhou

et al. 2024

BMC Microbiol

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Background Severe burns may alter the stability of the intestinal flora and affect the patient’s recovery process. Understanding the characteristics of the gut microbiota in the acute phase of burns and their association with phenotype can help to accurately assess the progression of the disease and identify potential microbiota markers. Methods We established mouse models of partial thickness deep III degree burns and collected faecal samples for 16 S rRNA amplification and high throughput sequencing at two time points in the acute phase for independent bioinformatic analysis. Results We analysed the sequencing results using alpha diversity, beta diversity and machine learning methods. At both time points, 4 and 6 h after burning, the Firmicutes phylum content decreased and the content of the Bacteroidetes phylum content increased, showing a significant decrease in the Firmicutes/Bacteroidetes ratio compared to the control group. Nine bacterial genera changed significantly during the acute phase and occupied the top six positions in the Random Forest significance ranking. Clustering results also clearly showed that there was a clear boundary between the communities of burned and control mice. Functional analyses showed that during the acute phase of burn, gut bacteria increased lipoic acid metabolism, seleno-compound metabolism, TCA cycling, and carbon fixation, while decreasing galactose metabolism and triglyceride metabolism. Based on the abundance characteristics of the six significantly different bacterial genera, both the XGboost and Random Forest models were able to discriminate between the burn and control groups with 100% accuracy, while both the Random Forest and Support Vector Machine models were able to classify samples from the 4-hour and 6-hour burn groups with 86.7% accuracy. Conclusions Our study shows an increase in gut microbiota diversity in the acute phase of deep burn injury, rather than a decrease as is commonly believed. Severe burns result in a severe imbalance of the gut flora, with a decrease in probiotics and an increase in microorganisms that trigger inflammation and cognitive deficits, and multiple pathways of metabolism and substance synthesis are affected. Simple machine learning model testing suggests several bacterial genera as potential biomarkers of severe burn phenotypes.

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“…Previous scientific data indicate that central nervous system (CNS) morbidity is significantly increased after burn trauma and a considerable number of burned patients with any severity showed neurological disorders, such as persistent headache, memory loss, and paresthesia [ 5 ]. Cognitive dysfunctions, such as memory impairment, are major neurological sequelae affecting the quality of life of burn patients [ 6 ]. The condition of acute neurological dysfunction caused by thermal trauma can be referred to as burn encephalopathy.…”

Section: Introductionmentioning

confidence: 99%

Complex Hippocampal Response to Thermal Skin Injury and Protocols with Hyperbaric Oxygen Therapy and Filipendula ulmaria Extract in Rats

Krstic,

Selakovic,

Jovicic

et al. 2024

IJMS

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The aim of this study was to evaluate the alterations of the hippocampal function that may be related to anxiogenic response to thermal skin injury, including the morpho-functional alterations, and the effects of hyperbaric oxygen (HBO) and Filipendula ulmaria (FU) extract in the treatment of anxiety-like behavior that coincides with thermal skin injury. A rat thermal skin injury experimental model was performed on 2-month-old male Wistar albino rats. The evaluated therapeutic protocols included HBO and/or antioxidant supplementation. HBO was applied for 7 days in the hyperbaric chamber (100% O2, 2.5 ATA, 60 min). Oral administration of FU extract (final concentration of 100 mg/kg b.w.) to achieve antioxidant supplementation was also applied for 7 days. Anxiety level was estimated in the open field and elevated plus-maze test, which was followed by anesthesia, sacrifice, and collection of hippocampal tissue samples. HBO treatment and FU supplementation significantly abolished anxiogenic response to thermal skin injury. This beneficial effect was accompanied by the reduction in hippocampal pro-inflammatory and pro-apoptotic indicators, and enhanced BDNF and GABA-ARα2S gene expression, previously observed in untreated burns. The hippocampal relative gene expression of melatonin receptors and NPY positively responded to the applied protocols, in the same manner as µ and δ opioid receptors, while the opposite response was observed for κ receptors. The results of this study provide some confirmations that adjuvant strategies, such as HBO and antioxidant supplementation, may be simultaneously applied in the treatment of the anxiety-like behavior that coincides with thermal skin injury.

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Researches on cognitive sequelae of burn injury: Current status and advances

Cited by 7 publications

References 135 publications

Inflammation and Organ Injury the Role of Substance P and Its Receptors

Inflammation and Organ Injury the Role of Substance P and Its Receptors

In silico analysis of intestinal microbial instability and symptomatic markers in mice during the acute phase of severe burns

Complex Hippocampal Response to Thermal Skin Injury and Protocols with Hyperbaric Oxygen Therapy and Filipendula ulmaria Extract in Rats

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