Nowadays, data mining methods are applied in various fields of science and technologies. The widespread application of these methods necessitates the development of procedures to improve the efficiency of basic methods. Often, the efficiency of approaches based on data mining methods significantly depends on the selection of numerical coefficients. Moreover, these numerical coefficients can be both parameters of the algorithm and parameters of the obtained solutions. Therefore, it is possible to apply optimization methods to determine the best values. Nowadays, one of the most efficient methods of real optimization is differential evolution. The paper presents the study the differential evolution application to optimize coefficients of a dynamic system model obtained by an approach based on a self-configuring genetic programming algorithm. Also, it considers optimization of threshold values for solving classification problems with decision trees. The paper considers the most popular methods for training decision trees. The selected tasks demonstrate the universality of the proposed modification, since they solve diverse tasks.Moreover, the applied data analysis methods belong to different classes. The results of numerical experiments are presented for these tasks. They prove efficiency of the proposed hybridization.