Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases

Kumar, Arvind; Asaf, Belal Bin; Puri, Harsh Vardhan; Abdellateef, Amr

doi:10.4103/0970-2113.213834

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Multiple different options are available for the treatment of tracheal stenosis involving endoscopic procedures, including laser ablation, electrocautery, argon-laser coagulation, application of mitomycin C topically, mechanical approaches including rigid bronchoscopy or balloon dilatation, cold therapies (cryotherapy, cryo-debridement, cryospray), and airway stenting [ 12 , 16 , 17 , 18 ]. However, mechanical endoscopic therapies can be problematic and may require repeated interventions, complicating the treatment, and the prognosis becomes poor [ 19 ]. The recurrence rate after bronchoscopic dilatation can be as high as 90% in complex TS.…”

Section: Reviewmentioning

confidence: 99%

Cryotherapy for the Treatment of Tracheal Stenosis: A Systematic Review

Hosna¹,

Rasool²,

Noff³

et al. 2023

Cureus

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Tracheal stenosis (TS) is an iatrogenic sequela after intubation or tracheostomy that is increasing despite technological improvement and skilled respiratory care in the ICU. According to the studies, the rate of TS varies from 10 to 22%, but only 1-2% of these stenoses are severe and present with inspiratory dyspnea that does not respond to medical management. Bronchoscopy is considered the most appropriate diagnostic test, and laser surgery and tracheobronchial stenting are the most commonly performed procedures for tracheal stenosis. However, alternative treatment options, including cryotherapy for inoperable patients, have yet to be studied widely. As the number of patients requiring ICU admission with mechanical intubation is increasing, it is crucial to acknowledge this complication and consider alternative management options. Here we present a review of the use of cryotherapy for post-intubation tracheal stenosis. Pubmed, Cochrane, and EMBASE databases were inquired for studies performed using the keywords 'airway stricture' OR 'airway obstruction' AND 'post-intubation' OR 'post-extubation' OR 'tracheostomy' AND 'cryotherapy'. After the primary and secondary screening, five studies were included in the analysis. We included 67 patients were included in the analysis, with a mean age of 50.2 (range: 42-55) years. Tracheal stenosis and subglottic stricture were the most common sites of stenosis. Twenty-nine patients were treated with cryotherapy only, while the rest 38 patients had cryotherapy followed by balloon dilation. After the intervention, 48 patients experienced improvement, five experienced no change in the symptoms, 13 patients were asymptomatic before the treatment, and one died. No complication was reported in 65 patients, with only minor complications reported in rest. Although, there is no clear treatment protocol for patients with inoperable tracheal stenosis. Our review demonstrates that cryotherapy for inoperable tracheal stenosis can be an acceptable alternative treatment with significant clinical improvement. Additionally, cryotherapy has fewer adverse effects compared to other treatment options.

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Section: Reviewmentioning

confidence: 99%

Cryotherapy for the Treatment of Tracheal Stenosis: A Systematic Review

Hosna¹,

Rasool²,

Noff³

et al. 2023

Cureus

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“…Benign tracheal stenosis has many causes, and its pathogenesis mainly results from trauma, injury and inflammation of tracheal mucosa during operation or intubation ( Wujtewicz et al, 2009 ; Bernon et al, 2013 ). Under these conditions, the fibroblasts begin to proliferate and migrate after induced by inflammatory mediators and growth factors, which increases the production of extracellular matrix and results in the formation of granulation, tissue scar, tissue hyperplasia, and tracheal stenosis ( Shitrit et al, 2010 ; Liang et al, 2015 ; Kumar et al, 2017 ; Oberg et al, 2018 ). However, the molecular mechanism underlying tracheal stenosis has not yet been clarified ( Farzanegan et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis

Zou

Cai

2022

Front. Genet.

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Objective: To explore the possible biological functions of the differentially expressed genes in patients with benign tracheal stenosis, and to provide a valuable molecular basis for investigating the pathogenesis of benign tracheal stenosis.Method: Whole transcriptome sequencing was performed on blood samples collected from patients with benign tracheal stenosis and normal controls. Differentially expressed mRNA, lncRNA, and circRNA were analyzed using the DESeq2 package. The protein interaction networks for differentially expressed mRNAs were constructed by STRING. The results of gene co-expression network analysis, Starbase database prediction, and differential gene expression were combined to construct a competing endogenous RNA network. The transcription factors of key genes were predicted using the Network Analyst database and a transcription factor-mRNA regulatory network was constructed. The classical pathways, intermolecular interaction networks, and upstream regulatory components of key genes were analyzed using Ingenuity Pathway Analysis (IPA). Finally, the DGIDB database was used to predict the potential therapeutic drugs to target the identified key genes.Result: Based on mRNA, lncRNA and circRNA expression data, we found that differentially expressed mRNAs were enriched in oxygen transport, neutrophil activation, immune response, and oxygen binding. Then the pearson correlation between mRNAs of 46 key genes and lncRNAs and cricRNAs were calculated, and the correlation greater than 0.9 were selected to construct the co-expression network of “mRNA-lncRA” and “mRNA-cricRNA.” Moreover, a “lncRNA-miRNA-mRNA” network and a “circRNA-miRNA-mRNA” network were constructed. IPA analysis showed that the 46 key genes were significantly associated with inflammatory activation and acute respiratory distress syndrome. The constructed TF-mRNA regulatory network was composed of 274 nodes and 573 interacting pairs. 251 potential therapeutic drugs were identified from the DGIDB database.Conclusion: This study analyzed the differential genes associated with benign tracheal stenosis and explored the potential regulatory mechanisms, providing a scientific reference for further studies on the pathogenesis of benign tracheal stenosis.

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Role of Primary Aetiology of Intubation in Acquired Laryngotracheal Stenosis: An Institutional Audit and Review of Literature

Saravanam

Manimaran

2020

Indian J Otolaryngol Head Neck Surg

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Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases

Cited by 6 publications

References 23 publications

Cryotherapy for the Treatment of Tracheal Stenosis: A Systematic Review

Cryotherapy for the Treatment of Tracheal Stenosis: A Systematic Review

Construction and Comprehensive Analysis of the ceRNA Network to Reveal Key Genes for Benign Tracheal Stenosis

Role of Primary Aetiology of Intubation in Acquired Laryngotracheal Stenosis: An Institutional Audit and Review of Literature

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