Resection margins of 2 versus 5 cm for cutaneous malignant melanoma with a tumor thickness of 0.8 to 2.0 mm: A randomized study by the Swedish Melanoma Study Group

Ringborg, Ulrik; Andersson, Ronny; Eldh, Jan; Glaumann, Barbro; Hafström, L; Jacobsson, Staffan; Jönsson, Per‐Ebbe; Johansson, Björn; Krysander, Lennart; Lagerlöf, B.

doi:10.1002/(sici)1097-0142(19960501)77:9<1809::aid-cncr8>3.0.co;2-6

Cited by 142 publications

(59 citation statements)

References 29 publications

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“…Consensus was achieved regarding data to be collected on patients with newly diagnosed cutaneous melanoma. Studies focused on excision margins, 1,2 head and neck melanomas, 3,4 chemotherapy, 5 and limb perfusion 6 have been published previously. Sweden, with 8.8 million inhabitants, is divided into 6 health care regions.…”

Section: Discussionmentioning

confidence: 99%

Invasive cutaneous malignant melanoma in Sweden, 1990–1999

Lindholm¹,

Andersson²,

Dufmats³

et al. 2004

Cancer

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BACKGROUND The objective of the current study was to compile prospective, population‐based data on cutaneous invasive melanomas in Sweden during the period from 1990 to 1999, to describe and analyze survival data and prognostic factors, and to make comparisons with previously published Swedish and international data. METHODS Twelve thousand five hundred thirty‐three patients, which included 97% of all registered melanomas in Sweden, were included and described. Among these, 9515 patients with clinical Stage I and II melanoma were included in an analysis of survival and in a univariate analysis, and 6191 patients were included in a multivariate analysis of prognostic factors. RESULTS There was no significant change in melanoma incidence during 1990–1999. Favorable prognostic factors were found, especially in younger and female patients, resulting in a relative 5‐year survival rate of 91.5%. In the multivariate analysis, significant factors that had a negative effect on survival were Clark level of invasion, Breslow thickness, ulceration, older patient age, trunk location, greatest tumor dimension, nodular histogenetic type, and male gender. CONCLUSIONS During the period from 1990 to 1999, the 5‐year survival of patients with malignant melanoma in Sweden was better compared with the previously reported rates in published, population‐based studies from Sweden, probably as a result of better secondary prevention due to better knowledge and awareness by both patients and the medical profession. The more favorable prognostic factors and the change in melanoma location found in younger patients, compared with earlier reports, may reflect changes in clothing as well as tanning habits; however, a decrease also was found in Clark Level II and thin melanomas for the same patient group. The authors concluded that further improvements can be achieved with better access to health care and with the use of early melanoma detection campaigns. Cancer 2004. © 2004 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Invasive cutaneous malignant melanoma in Sweden, 1990–1999

Lindholm¹,

Andersson²,

Dufmats³

et al. 2004

Cancer

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“…No statistically significant difference was observed in distant metastases or overall survival. This conclusion was counter-intuitive and difficult to accept, and so at least four other prospective randomized studies were conducted between 1980 and 2000 to determine the optimal margin of excision for cutaneous melanomas (Balch et al, 2001;Balch et al, 1993;Cohn-Cedermark et al, 2000;Ringborg et al, 1996;Thomas et al, 2004;Veronesi and Cascinelli, 1991;Veronesi et al, 1988). These trials compared various margins from 1 to 5 cm, in melanomas of different thickness and in a total of 2,861 patients.…”

Section: Tumour Excisionmentioning

confidence: 99%

Current Insight Into the Metastatic Process and Melanoma Cell Dissemination

Bourgault‐Villada¹,

Hong²,

Khoo³

et al. 2011

Research on Melanoma - A Glimpse Into Current Directions and Future Trends

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“…Tab. 1) war die Erarbeitung der prognostisch wichtigen Melanomkriterien auf der Basis der mikromorphologischen Ermittlung der Tumoreindringtiefe nach Clark und der Tumordickenmessung nach Breslow [9,26].…”

Section: Tab 1 Ergebnisse Prospektiver Randomisierter Studien Zum Seunclassified

Malignes Melanom der Haut

Sebastian

2006

Hautarzt

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Excision is the treatment of choice in stage I malignant melanoma. As supported by several controlled clinical studies, reduced safety surgical margins from 0.5 to 2 cm are sufficient. Most surgical defects can be closed by simple skin flap techniques. In critical anatomic sites (e. g. face, hand, foot) micrographic surgery is the therapy of choice. Sentinel lymph node biopsy (SLNB) was proposed as a minimally-invasive procedure for the histopathologic staging of the regional lymph nodes. Today SLNB is standard in the diagnostic approach to melanomas thicker than 1 mm. The therapeutic relevance of SLNB is unclear. The most common sign of tumor progression is involvement of regional lymph nodes. The treatment of choice in patients with neck metastases is the radical, modified or selective neck dissection. In the case of axillary metastases, levels I-III of the axillary lymph nodes are excised. With groin metastases, superficial inguinal dissection is usually preferred. There are no randomized controlled trials comparing the outcome of combined inguinal and pelvic lymph node dissection and superficial inguinal lymph node dissection.

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Resection margins of 2 versus 5 cm for cutaneous malignant melanoma with a tumor thickness of 0.8 to 2.0 mm: A randomized study by the Swedish Melanoma Study Group

Abstract: We recommend an excision with a margin of 2 cm for cutaneous malignant melanoma with a tumor thickness > 0.8 and < or = 2.0 mm.

Cited by 142 publications

References 29 publications

Invasive cutaneous malignant melanoma in Sweden, 1990–1999

Invasive cutaneous malignant melanoma in Sweden, 1990–1999

Current Insight Into the Metastatic Process and Melanoma Cell Dissemination

Malignes Melanom der Haut

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