Resection of recurrent pulmonary metastases in patients with osteosarcoma

Briccoli, A; Rocca, Michele; Salone, Mariacristina; Bacci, Gaetano; Ferrari, Stefano; Balladelli, Alba; Mercuri, Mario

doi:10.1002/cncr.21369

Cited by 135 publications

(93 citation statements)

References 59 publications

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“…In a previous systematic review of reported outcome in approximately 1,800 osteosarcoma patients with pulmonary metastases from 1939 to 2007, the main prognostic factor affecting survival was found to be complete surgical remission [1,[4][5][6]8]. In addition, DFI, as well as number and localization of metastases, has also been found to be significantly associated with survival [3,[5][6][7][9][10][11].…”

Section: Discussionmentioning

confidence: 97%

“…The number of metastases has been a matter of interest since the study by Putnam et al who described an association between decreased survival and more than three metastases on preoperative CT [12]. However, most studies do not describe how the cut-off point for the number of nodules was determined, and therefore cut-offs range between "more than one" and "six nodules or more" [1][2][3][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

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Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Matsubara

Mori

Kinoshita

et al. 2015

Journal of Respiratory Medicine

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.Purpose. To identify prognostic factors for metastatic osteosarcoma patients and establish indication for repeat metastasectomy. Methods. Data from 37 patients with pulmonary metastasis from osteosarcoma who underwent metastasectomy in our institute from 1979 to 2013 were retrospectively reviewed. Results. Prognostic factors analyzed were age, sex, maximal diameter of the tumor at first pulmonary metastasectomy, total number of resected pulmonary metastases at first metastasectomy, number of surgeries, and disease free interval. In our analysis, characteristics associated with an increased overall survival were age > 15 years and fewer metastases (≤3). Of the 37 patients, 13 underwent repeat metastasectomy after the first metastasectomy. Of the 7 patients that underwent only two metastasectomies, three remained disease-free. In contrast, all six patients that underwent three or more metastasectomies died of relapse. Patients who had five or less lesions at second metastasectomy showed better survival compared to those who had six or more lesions. Conclusion. Age > 15 years and number of metastases at first metastasectomy were independent prognostic factors. Metastasectomy may provide curative treatment even in cases requiring repeat surgery. The number of metastases at second metastasectomy may be a potential predictor of the need for repeat surgery.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Matsubara

Mori

Kinoshita

et al. 2015

Journal of Respiratory Medicine

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“…3,5,7,13,15,17,18,19 : 1. Autologous bone graft: This form of graft has no rejection and a low rate of infection.…”

Section: © the Foot And Ankle Online Journal 2010mentioning

confidence: 99%

Chondroblastic Osteosarcoma of the Lower Tibia: A case report

Jerome¹

2010

FAOJ

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steosarcoma is a bone tumor that can occur in any bone. It most commonly occurs in the long bones of the extremities near metaphyseal growth plates. The most common sites are femur (42%), tibia (19%), and humerus (10%). Other locations include the skull or jaw (8%) and pelvis (8%). A number of variants of osteosarcoma include conventional types (i.e osteoblastic, chondroblastic, fibroblastic types) and telangiectatic, multifocal, parosteal, and periosteal types. Case ReportA 13 year-old boy came to our out-patient department with pain of the left ankle for 3 weeks duration. He was consulting a local practitioner for the same problem and got some relief after taking nonsteroidal anti-inflammatory drugs. There was no history of trauma, evening rise of temperature, weight loss, or loss of appetite. On examination, the left ankle had a mild to moderate swelling in the distal end of the tibia. It was not warm, but tender on palpation. There was no bony crepitus or abnormal mobility felt in the distal end of left tibia. His blood parameters including lactate dehydrogenase (LDH) and Alkaline Phosphatase were within normal limits. Radiographs showed a large sclerotic lesion, soft tissue permeation in the lower end of tibia with elevation of the periosteum (Codman triangle) and extension of the lesion through the periosteum resulting in a sunburst appearance. (Figs. 1 and 2)

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“…However, in the last two decades, the overall survival of OS patients with local disease has plateaued 4,5 . Moreover, 30-40% of these patients relapse within 3 years after diagnosis and patients with metastatic disease continue to have a poor survival of 20-30% 4,6,7 . To improve the outcome of these patients, new therapeutic strategies need to be developed.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells <em>In Vitro</em>

Meier

Campanile

Botter

et al. 2014

JoVE

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In recent years, there has been the difficulty in finding more effective therapies against cancer with less systemic side effects. Therefore Photodynamic Therapy is a novel approach for a more tumor selective treatment.Photodynamic Therapy (PDT) that makes use of a nontoxic photosensitizer (PS), which, upon activation with light of a specific wavelength in the presence of oxygen, generates oxygen radicals that elicit a cytotoxic response 1 . Despite its approval almost twenty years ago by the FDA, PDT is nowadays only used to treat a limited number of cancer types (skin, bladder) and nononcological diseases (psoriasis, actinic keratosis) 2 .The major advantage of the use of PDT is the ability to perform a local treatment, which prevents systemic side effects. Moreover, it allows the treatment of tumors at delicate sites (e.g. around nerves or blood vessels). Here, an intraoperative application of PDT is considered in osteosarcoma (OS), a tumor of the bone, to target primary tumor satellites left behind in tumor surrounding tissue after surgical tumor resection. The treatment aims at decreasing the number of recurrences and at reducing the risk for (postoperative) metastasis.In the present study, we present in vitro PDT procedures to establish the optimal PDT settings for effective treatment of widely used OS cell lines that are used to reproduce the human disease in well established intratibial OS mouse models. The uptake of the PS mTHPC was examined with a spectrophotometer and phototoxicity was provoked with laser light excitation of mTHPC at 652 nm to induce cell death assessed with a WST-1 assay and by the counting of surviving cells. The established techniques enable us to define the optimal PDT settings for future studies in animal models. They are an easy and quick tool for the evaluation of the efficacy of PDT in vitro before an application in vivo.

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Resection of recurrent pulmonary metastases in patients with osteosarcoma

Cited by 135 publications

References 59 publications

Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Chondroblastic Osteosarcoma of the Lower Tibia: A case report

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells <em>In Vitro</em>

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