Resection Rate and Outcome of Pulmonary Resections for Non–Small-Cell Lung Cancer: A Nationwide Study From Iceland

Þorsteinsson, Húnbogi; Alexandersson, Ásgeir; Óskarsdóttir, Guðrún; Skúladóttir, Rut; Ísaksson, Helgi J.; Jónsson, Steinn; Guðbjartsson, Tómas

doi:10.1097/jto.0b013e318252d022

Cited by 39 publications

(39 citation statements)

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“…In comparable studies, the OS at 5 years usually lies between 40% and 70% [9,21]. The OS found in the present study is therefore in line with other reports.…”

Section: Discussionsupporting

confidence: 83%

“…Lobectomy is considered the gold standard of treatment for NSCLC [4], as numerous studies have shown that lobectomy has better outcome than sublobar resections with regard to both recurrence of cancer and long-term survival [8,9]. Until recently, segmentectomy and wedge resection have been used when pulmonary function or other comorbidities pose a high operative risk.…”

Section: Introductionmentioning

confidence: 99%

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Lobectomy for non-small cell lung carcinoma: a nationwide study of short- and long-term survival

et al. 2017

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Introduction: Lobectomy is the standard curative treatment for non-small cell carcinoma (NSCLC) of the lung. Most studies on lobectomy have focused on short-term outcome and 30-day mortality. The aim of this study was to determine both short-term and long-term surgical outcome in all patients who underwent lobectomy for NSCLC in Iceland over a 24-year period. Material and methods: The study involved 489 consecutive patients with NSCLC who underwent lobectomy with curative intent in Iceland, 1991Iceland, -2014. Patient demographics, pTNM stage, rate of perioperative complications, and 30-day mortality were registered. Overall survival was analyzed with the Kaplan-Meier method. The Cox proportional hazards model was used to evaluate factors that were prognostic of overall mortality. To study trends in survival, the study period was divided into six 4-year periods. The median follow-up time was 42 months and no patients were lost to follow-up. Results: The average age of the patients was 67 years and 53.8% were female. The pTNM disease stage was IA in 148 patients (30.0%), IB in 125 patients (25.4%), IIA in 96 patients (19.5%), and IIB in 50 patients (10.1%), but 74 (15.0%) were found to be stage IIIA, most often diagnosed perioperatively. The total rate of major complications was 4.7%. Thirty-day mortality was 0.6% (three patients). One-and 5-year overall survival was 85.0% and 49.2%, respectively, with 3-year survival improving from 48.3% to 72.8% between the periods 1991-1994 and 2011-2014 (p ¼ .0004). Advanced TNM stage and age were independent negative prognostic factors for all-cause mortality, and later calendar year and free surgical margins were independent predictors of improved survival. Conclusions: The short-term outcome of lobectomy for NSCLC in this population-based study was excellent, as reflected in the low 30-day mortality and low rate of major complications. The long-term survival was acceptable and the overall 3-year survival had improved significantly during the study period.

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“…In comparable studies, the OS at 5 years usually lies between 40% and 70% [9,21]. The OS found in the present study is therefore in line with other reports.…”

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Lobectomy for non-small cell lung carcinoma: a nationwide study of short- and long-term survival

et al. 2017

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“…The 46.8% combined 5-year survival rate for stage-I and stage-II lung cancers is significantly below the rate for most other cancers (Thorsteinsson et al, 2012). Adenocarcinoma is the most prevalent histologic type of lung cancer in both genders in Taiwan (Hsu et al, 2012) and pulmonary adenocarcinoma is the most prevalent histologic type of cancer in non-smoking women.…”

Section: Introductionmentioning

confidence: 99%

The effect of gender on health-related quality of life and related factors in post-lobectomy lung-cancer patients

Chang

Lin

Hsu

et al. 2015

European Journal of Oncology Nursing

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“…It has also been reported to be affected by factors outside the scope of staging components such as the histological type and differentiation grade of the tumor as well as type of surgical operation [3].…”

Section: Introductionmentioning

confidence: 99%

Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer

Taylan

Arınç²,

Misirlioglu³

et al. 2016

J Clin Exp Invest

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Objective: The early and local advanced stages (IA-IIIA) of non-small cell lung cancer (NSCLC) warrant the curative treatment approach of surgery. However, despite the surgical approach, survival depends on a number of factors. The aim of the study was to examine the factors that affect survival in operated NSCLC patients with these stages.Methods: A cohort of 231 operated patients with IA, IB, IIA, IIB, and IIIA stages of NSCLC were analyzed. The effects of age, sex, comorbidity, performance status, histopathology of the tumor, T stage, N stage, pleural invasion, surgical resection type and postoperative resection margin invasion on the survival of the patients were examined with KaplanMeier and Cox Regression analyses.Results: Advanced age (OR=1.042 for every passing year, CI=1.020-1.064), adenocarcinoma histopathology (OR=1.676 CI=1.178-2.384), N2 invasion (OR=2.389 CI=1.46-4.239), pleural invasion (OR=2.403 CI=1.569-3.678), resection margin invasion (OR=2.401, CI=1.141-5.048) and pneumonectomy as the type of surgical operation (OR=2.313, CI=1.467-3.647) were found to be independent prognostic factors of mortality. Conclusion:Follow-up of the NSCLC cases with advanced age, an adenocarcinoma type, visceral pleural invasion, N2-lymph node invasion, a history of pneumonectomy, and a resection margin invasion should be undertaken more attentively during planning of surgical operation and postoperative period. Sonuç: İleri yaştaki, adenokanser tipine sahip, viseral plevra invazyonu veya N2 tutulumu olan, pnömomonektomi operasyonu geçiren ve cerrahi sınırda tümör pozitifliği görülen opere erken ve lokal ileri evre KHDAK tanılı hastaların perioperatif ve postoperatif dönemdeki takipleri dikkatli planlanmalıdır.Anahtar kelimeler: sağkalım, mortalite, performans skoru, opere edilmiş, küçük hücreli olmayan akciğer kanseri Taylan M, et al. Survival in Operated Non-Small Cell Lung Cancer

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Resection Rate and Outcome of Pulmonary Resections for Non–Small-Cell Lung Cancer: A Nationwide Study From Iceland

Abstract: Compared with most other published studies, the SRR of NSCLC in Iceland is high. Short-term outcome is good, with a low rate of major complications and an operative mortality of only 1.0%. Five-year survival improved significantly over the study period.

Cited by 39 publications

References 30 publications

Lobectomy for non-small cell lung carcinoma: a nationwide study of short- and long-term survival

Lobectomy for non-small cell lung carcinoma: a nationwide study of short- and long-term survival

The effect of gender on health-related quality of life and related factors in post-lobectomy lung-cancer patients

Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer

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