Reserpine in Schizophrenia

Another view of the history of antipsychotic drug discovery and development

“…2 Reserpine, an antihypertensive compound that was later determined to reduce storage and release of dopamine at a presynaptic level was tried with some success to benefit schizophrenia. 3 Before the 1950s there were other heroic attempts, often with severe adverse effects and without known efficacy. These have been cataloged elsewhere.…”