Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice

Samad, Noreen; Manzoor, Natasha; Muneer, Zahra; Bhatti, Sheraz Ahmed; Imran, Imran

doi:10.1007/s11011-021-00789-2

Cited by 15 publications

(6 citation statements)

References 85 publications

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“…Studies have reported that TQ can increase cellular antioxidants and can upregulate SOD, CAT, and GPx genes in a dosedependent manner. [39][40][41] In our study, TQ treatment markedly improved the cellular antioxidant levels suggesting its antilipid peroxidative effect.…”

Section: Tq Treatment Suppresses Proliferation Of Lung Alveolar Epith...supporting

confidence: 65%

Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene‐induced experimental lung cancer

Nithya

Rajasekaran

Vanitha

et al. 2022

J Biochem & Molecular Tox

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Several studies have suggested that increased consumption of phytochemicals is a comparatively easy and practical strategy to significantly decrease the incidence of cancer. In the present study, we have reported the protective effect of a natural compound, thymoquinone (TQ) against benzo(a)pyrene (B(a)P)‐induced lung carcinogenesis in Swiss albino mice. B(a)P (50 mg/kg body weight) was administered twice weekly for four successive weeks and left until 20 weeks to induce lung cancer in mice. TQ (20 mg/kg body weight) was given orally as a pretreatment and posttreatment drug to determine its chemopreventive and therapeutic effects. B(a)P‐induced lung cancer‐bearing animals displayed cachexia‐like symptoms along with an abnormal increase in lung weight and the activities of marker enzymes adenosine deaminase, aryl hydrocarbon hydroxylase, gamma‐glutamyl transpeptidase, 5′‐nucleotidase and lactate dehydrogenase; tumor marker carcinoembryonic antigen levels. Furthermore, B(a)P‐induced animals showed elevated levels of lipid peroxides with subsequent depletion in the antioxidant status and histological aberrations. These anomalies were accompanied by increased expressions of proliferating cell nuclear antigen and cyclin D1 in the lung sections derived from B(a)P‐induced animals. On TQ treatment, all the above alterations were returned to near normalcy. Furthermore, TQ administration in B(a)P‐induced animals downregulated phosphatidylinositol 3‐kinase/protein kinase B signaling pathway and induced apoptosis as evidenced by a decrease in cytochrome c, proapoptotic Bax, caspase‐3, and p53 with a parallel increase in antiapoptotic Bcl‐2. Our present results demonstrate the potential effectiveness of TQ as an antioxidant, antiproliferative, and apoptotic agent against B(a)P‐induced experimental lung tumorigenesis.

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Section: Tq Treatment Suppresses Proliferation Of Lung Alveolar Epith...supporting

confidence: 65%

Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene‐induced experimental lung cancer

Nithya

Rajasekaran

Vanitha

et al. 2022

J Biochem & Molecular Tox

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“…Twenty-four rats were divided into following sets with n = 06 as previous studies reported ( Samad et al, 2022a , Samad et al, 2022b , Samad et al, 2022c , Samad et al, 2021 ); (i) water + water (ii) water + M.M. (iii) water + D-Gal (iv) D-Gal + M.M.…”

Section: Methodsmentioning

confidence: 99%

“…Behavioral activities i.e., Elevated Plus-Maze (EPM) and Light/dark activity (LDA) tests conducted to evaluate anxiety profile; Forced Swim Test (FST) conducted to assess depressive symptoms and Morris Water Maze (MWM) test (acquisition, short-term-memory (STM), long-term-memory (LTM) for cognitive functions. After behavioral activities rats were decapitated using guillotine ( Samad et al, 2021 ) and their brains collected from skull as reported previously ( Tabassum et al, 2017 ), and then frozen at −20 °C for further neurochemical and biochemical assessments (Experiment layout Fig. 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…Aging progression is associated with many neurological problems i.e. anxiety, depression ( Samad et al, 2022a , Samad et al, 2022b , Samad et al, 2022c , Samad et al, 2021 ), cognitive impairment ( Samad et al, 2020 ; 2019) etc. D-galactose (D-Gal) model is one of the progressive aging models, having lesser side effects and mortality rate ( St-Pierre et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

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Mitigation of behavioral deficits and cognitive impairment by antioxidant and neuromodulatory potential of Mukia madrespatana in D-galactose treated rats

Samad,

Azdee,

Imran

et al. 2023

Saudi Journal of Biological Sciences

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“…TQ is an important major phytoconstituent of NS and its volatile oil. TQ stimulates a variety of pharmacological effects, including hepatoprotective [ 24 , 25 ], nephroprotective [ 26 , 27 ], antimicrobial [ 28 ], anti-inflammatory [ 29 , 30 ], antioxidant [ 30 ], antifungal [ 31 ], anticancer [ 32 , 33 , 34 ], anti-Alzheimer [ 35 , 36 , 37 ], anti-Parkinson [ 38 , 39 , 40 ], anticonvulsant [ 41 , 42 ], antidepression [ 43 , 44 ], and many more (illustrated in Figure 3 ).…”

Section: Pharmacology Of N Sativamentioning

confidence: 99%

Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting Nigella sativa and Its Active Constituent Thymoquinone

et al. 2022

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Osteoporosis, a chronic bone disorder, is one of the leading causes of fracture and morbidity risk. Numerous medicinally important herbs have been evaluated for their efficacy in improving bone mass density in exhaustive preclinical and limited clinical studies. Nigella sativa L. has been used as local folk medicine, and traditional healers have used it to manage various ailments. Its reported beneficial effects include controlling bone and joint diseases. The present manuscript aimed to provide a sound discussion on the pharmacological evidence of N. sativa and its active constituent, thymoquinone, for its utility in the effective management of osteoporosis. N. sativa is reported to possess anti-IL-1 and anti-TNF-α-mediated anti-inflammatory effects, leading to positive effects on bone turnover markers, such as alkaline phosphatase and tartrate-resistant acid phosphatase. It is reported to stimulate bone regeneration by prompting osteoblast proliferation, ossification, and decreasing osteoclast cells. Thymoquinone from N. sativa has exhibited an antioxidant effect on bone tissue by reducing the FeNTA-induced oxidative stress. The present manuscript highlights phytochemistry, pharmacological effect, and the important mechanistic perspective of N. sativa and its active constituents for the management of osteoporosis. Further, it also provides sound discussion on the utilization of a nanotechnology-mediated drug delivery approach as a promising strategy to improve the therapeutic performance of N. sativa and its active constituent, thymoquinone, in the effective management of osteoporosis.

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Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice

Cited by 15 publications

References 85 publications

Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene‐induced experimental lung cancer

Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene‐induced experimental lung cancer

Mitigation of behavioral deficits and cognitive impairment by antioxidant and neuromodulatory potential of Mukia madrespatana in D-galactose treated rats

Utilization of Nanotechnology to Improve Bone Health in Osteoporosis Exploiting Nigella sativa and Its Active Constituent Thymoquinone

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