Reserpine-Induced Depression and Other Neurotoxicity: A Monoaminergic Hypothesis

Govindarajulu, Manoj; Shankar, Tharanath; Patel, Sagar P.; Fabbrini, Mary; Manohar, Amulya; Ramesh, Sindhu; Boralingaiah, Prashanth; Sharma, Sreelakshmi; Clark, Randall; DeRuiter, Jack; Moore, Timothy; Agrawal, D. C.; Dhanasekaran, Muralikrishnan

doi:10.1007/978-981-33-4141-8_12

Cited by 4 publications

(2 citation statements)

References 60 publications

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“…The monoaminergic hypothesis states that the dysfunction of the monoaminergic neurotransmitter system in the body can result in depression (Govindarajulu et al, 2021). Catecholamines, composed of dopamine (DA), norepinephrine (NE), and epinephrine, are monoamine neurotransmitters, similar to indoleamines, especially serotonin (5-HT).…”

Section: Mechanisms Underlying the Antidepressant Effects Of Querceti...mentioning

confidence: 99%

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

et al. 2022

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Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, the side effects of currently used antidepressants greatly reduce the compliance of patients. Quercetin is a flavonol present in fruits, vegetables, and Traditional Chinese medicine (TCM) that has been proved to have various pharmacological effects such as anti-depressant, anti-cancer, antibacterial, antioxidant, anti-inflammatory, and neuroprotective. This review summarizes the evidence for the pharmacological application of quercetin to treat depression. We clarified the mechanisms of quercetin regulating the levels of neurotransmitters, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal (HPA) axis dysfunction, and reducing inflammatory states and anti-oxidative stress. We also summarized the antidepressant effects of some quercetin glycoside derivatives to provide a reference for further research and clinical application.

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Section: Mechanisms Underlying the Antidepressant Effects Of Querceti...mentioning

confidence: 99%

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

et al. 2022

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“…Depressive disorders are expensive and are associated with significant morbidity and mortality as well [ 5 ]. There are some hypotheses related to the pathophysiology of depression, such as the neurotrophic hypothesis (reduction of a neurotrophic factor in the brain, imbalance of monoaminergic systems (imbalance of serotonergic, noradrenergic and dopaminergic neurotransmission), and HPA axis dysfunction (hypercortisolemia) hypothesis [ 6 , 7 ]. Clinical evidence also suggested that disorders of serotonin (5-HT) [ 8 ], norepinephrine (NE), and dopaminergic neurotransmission in the central nervous system are the main causes of depression.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like Effects of Polygonum minus Aqueous Extract in Chronic Ultra-Mild Stress-Induced Depressive Mice Model

Bashir

Aziz

Noor

2022

Behavioral Sciences

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Depression is the most common behavior disorder that leads to many disabilities. The main aim of this study was to evaluate the effects of a Polygonum minus (P. minus) aqueous extract on chronic ultra-mild stress (CUMS)-induced depressive mice model. Chronic ultra-mild stress can disturb the neurotransmitters levels and plasticity of the hippocampus. Balb/c male mice were used in this study, which consisted of six groups (n = 14). Treatment was given for eight weeks, and chronic ultra-mild stress was applied for six weeks. Commercially available P. minus extract (BioKesum®) was used in this study. The behavior and neurochemical parameters were investigated through behavioral Tests and ELISA assays. P. minus administration significantly (p < 0.05) restored CUMS-induced behavior abnormalities, decreased the immobility time, and increased the sucrose preference and increased the spatial memory. P. minus treatment also showed the decreased level of serum corticosterone and increased the level of hippocampal neurotransmitters (Serotonin and Norepinephrine) significantly (p < 0.05). The brain-derived neurotrophic factor (BDNF) level also increased significantly in both the prefrontal cortex and hippocampus (p < 0.05). P. minus treatment exhibited significant (p < 0.05) reduction of Monoamine Oxidase-A (MAO-A) in the hippocampus. These findings indicate that P. minus aqueous extract exhibits antidepressant effects, including decreased immobility time, increased spatial memory, reduced corticosterone, increased BDNF level, and reduced MAO-A enzyme level with increasing the monoamines (serotonin and norepinephrine) in the hippocampus.

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Effects of different exercise modalities on pediatric and adolescent populations with developmental disorders: a network meta-analysis of randomized controlled trials

Jia,

Hu,

Yang

2024

Eur J Pediatr

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Reserpine-Induced Depression and Other Neurotoxicity: A Monoaminergic Hypothesis

Cited by 4 publications

References 60 publications

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

Antidepressant-like Effects of Polygonum minus Aqueous Extract in Chronic Ultra-Mild Stress-Induced Depressive Mice Model

Effects of different exercise modalities on pediatric and adolescent populations with developmental disorders: a network meta-analysis of randomized controlled trials

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